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Pharmaceutisch Weekblad

, Volume 8, Issue 6, pp 281–285 | Cite as

Influence of salicylate and anaesthesia on the rectal absorption of theophylline in rats

  • E. J. van Hoogdalem
  • A. G. De Boer
  • D. D. Breimer
Original Articles
  • 18 Downloads

Abstract

The effect of sodium salicylate and anaesthesia on the rectal absorption of theophylline was evaluated in rats. Theophylline proved to be slowly but completely absorbed on rectal infusion in conscious rats, compared with intravenous infusion. Pentobarbital anaesthesia did not influence absorption. In contrast to literature data, the results with salicylate showed that rectal absorption of theophylline was not enhanced.

Key words

Absorption Administration, rectal Anesthesia Drug therapy, combination Pentobarbital Salicylates Theophylline 

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Copyright information

© Bohn, Scheltema & Holkema 1986

Authors and Affiliations

  • E. J. van Hoogdalem
    • 1
  • A. G. De Boer
    • 1
  • D. D. Breimer
    • 1
  1. 1.Division of Pharmacology, Sylvius LaboratoriesCenter for Bio-Pharmaceutical SciencesLeidenThe Netherlands

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