Pharmaceutisch Weekblad

, Volume 8, Issue 6, pp 281–285 | Cite as

Influence of salicylate and anaesthesia on the rectal absorption of theophylline in rats

  • E. J. van Hoogdalem
  • A. G. De Boer
  • D. D. Breimer
Original Articles


The effect of sodium salicylate and anaesthesia on the rectal absorption of theophylline was evaluated in rats. Theophylline proved to be slowly but completely absorbed on rectal infusion in conscious rats, compared with intravenous infusion. Pentobarbital anaesthesia did not influence absorption. In contrast to literature data, the results with salicylate showed that rectal absorption of theophylline was not enhanced.

Key words

Absorption Administration, rectal Anesthesia Drug therapy, combination Pentobarbital Salicylates Theophylline 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Touitou E, Donbrow M. Promoted rectal absorption of insulin: formulative parameters involved in the absorption from hydrophylic bases. Int J Pharm 1983;15:13–24.CrossRefGoogle Scholar
  2. 2.
    Morimoto K, Hama I, Nakamoto Y, Takeeda T, Hirano E, Morisaka K. Pharmaceutical studies of polyacrylic acid aqueous gel bases: absorption of insulin from polyacrylic acid aqueous gel bases following rectal administration in alloxan diabetic rats and rabbits. J Pharm Dyn 1980;3:24–32.Google Scholar
  3. 3.
    Bar-On H, Ziv E. Rectal administration of insulin. Isr J Med Sci 1984;20:173–5.PubMedGoogle Scholar
  4. 4.
    Nishihata T, Okamura Y, Kamada A, Higuchi T, Vagi T, Shichiri M. Enhanced bioavailability of insulin after rectal administration with enamine as adjuvant in depancreatized dogs. J Pharm Pharmacol 1985;37:22–6.PubMedGoogle Scholar
  5. 5.
    Nishihata T, Rytting JH, Kamada A, Higuchi T, Routh M, Caldwell L. Enhancement of rectal absorption of insulin using salicylates in dogs. J Pharm Pharmacol 1983;35:148–51.PubMedGoogle Scholar
  6. 6.
    Muranushi N, Kinugawa M, Nakijima Y, Muranishi S, Sezaki H. Mechanism for the inducement of the intestinal absorption of poorly absorbed drugs by mixed micelles. I. Effect of various lipid-bile salts mixed micelles on the intestinal absorption of streptomycin in rat. Int J Pharm 1980;4:271–9.CrossRefGoogle Scholar
  7. 7.
    Fix JA, Leppert PS, Porter PA, Alexander J. The use of phenothiazines to enhance the rectal absorption of water-soluble compounds. J Pharm Pharmacol 1984;36:286–8.PubMedGoogle Scholar
  8. 8.
    Nishihata T, Rytting JH, Higuchi T. Effects of salicylate on rectal absorption of theophylline. J Pharm Sci 1981;70:71–5.PubMedGoogle Scholar
  9. 9.
    Nishihata T, Tomida H, Frederick G, Rytting JH, Higuchi T. Comparison of the effects of sodium salicylate, disodium ethylenediaminetetraacetic acid and polyoxyethylene-23-laurylether as adjuvants for the rectal absorption of sodium cefoxitin. J Pharm Pharmacol 1985;37:159–63.PubMedGoogle Scholar
  10. 10.
    Nishihata T, Rytting JH, Higuchi T. Effect of salicylate on the rectal absorption of lidocaine, levodopa and cefmetazole in rats. J Pharm Sci 1982;71:869–72.PubMedGoogle Scholar
  11. 11.
    Bolme P, Edlund PO, Eriksson M, Paalzow L, Winbladh B. Pharmacokinetics of theophylline in young children with asthma: comparison of rectal enema and suppositories. Eur J Clin Pharmacol 1979;16:133–9.PubMedGoogle Scholar
  12. 12.
    Teunissen MWE, Brorens ION, Geerlings JM, Breimer DD. Dose-dependent elimination of theophylline in rats. Xenobiotica 1985;15:165–71.PubMedGoogle Scholar
  13. 13.
    Chiou WL. Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J Pharmacokinet Biopharm 1978;6:539–46.CrossRefPubMedGoogle Scholar
  14. 14.
    Kleinbloesem CH, Van Harten J, De Leede LGJ, Van Brummelen P, Breimer DD. Nifedipine kinetics and dynamics during rectal infusion to steady state with an osmotic system. Clin Pharmacol Ther 1984;36:396–401.PubMedGoogle Scholar
  15. 15.
    Johannessen W, Gadeholt G, Aarbakke J. Effects of diethyl ether anaesthesia on the pharmacokinetics of antipyrine and paracetamol in the rat. J Pharm Pharmacol 1981;33:365–8.PubMedGoogle Scholar
  16. 16.
    Vermeulen NPE, Danhof M, Setiawan I, Breimer DD. Disposition of hexobarbital in the rat. Estimation of ‘first-pass’ elimination and influence of ether anesthesia. J Pharmacol Exp Ther 1983;226:201–5.PubMedGoogle Scholar
  17. 17.
    Daemen MJAP, Thijssen HHW, Vervoort-Peters HTM, Smits JFM, Struyker-Boudier HAJ. The effect of pentobarbitone anaesthesia and hypothermia on the hepatic clearance of indocyanine green andS(−)-acenocoumarol in the rat. J Pharm Pharmacol 1986;38:122–5.PubMedGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1986

Authors and Affiliations

  • E. J. van Hoogdalem
    • 1
  • A. G. De Boer
    • 1
  • D. D. Breimer
    • 1
  1. 1.Division of Pharmacology, Sylvius LaboratoriesCenter for Bio-Pharmaceutical SciencesLeidenThe Netherlands

Personalised recommendations