Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1698–1703 | Cite as

Zinc and cerium sulfadiazine, zinc sulfathiazole. Real compounds or physical mixtures?

  • A. Bult
  • N. Hulsing
  • J. W. Weyland
Original Articles


Zinc and cerium sulfadiazine (SD) are recommended for use in topical burn therapy. In the literature the compositions Zn(SD)2 and Ce(SD)3 were suggested for these metal compounds prepared in aqueous solution. Actually a physical mixture of the metal hydroxide and free sulfadiazine (HSD) is formed. The presence of HSD in the mixture makes these products less suitable in local therapy. Preparation in ethanol results in a Zn-SD compound of indeterminate composition. The antibacterial zinc compound of sulfathiazole (HST) prepared in aqueous solution has the composition Zn(ST)2.


Public Health Zinc Aqueous Solution Internal Medicine Hydroxide 
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Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • A. Bult
    • 1
  • N. Hulsing
    • 1
  • J. W. Weyland
    • 1
  1. 1.Laboratory for Pharmaceutical and Analytical ChemistryState UniversityAw GroningenThe Netherlands

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