Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1438–1443 | Cite as

Spectrofluorimetric determination of adrenaline and related compounds in pharmaceutical preparations

  • W. J. M. Underberg
  • G. Wiese
Oorspronkelijke Artikelen


A simple and rapid method for the spectrofluorimetric determination of adrenaline and some related compounds in pharmaceutical preparations was developed. The method is based on the measurement of the fluorescence of the compounds at their respective emission maxima after excitation of solutions in 0. 1 M sodium dihydrogen phosphate. The influence of several additives (drugs, preservatives, buffers, etc.) was studied. With the method amounts of 1–4μg/ml of the various drugs could be determined. The method was tested with a variety of pharmaceutical formulations.


Public Health Sodium Phosphate Internal Medicine Adrenaline 
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Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • W. J. M. Underberg
    • 1
  • G. Wiese
    • 1
  1. 1.Department of Analytical Pharmacy, Subfaculty of PharmacyState University of UtrechtGH UtrechtThe Netherlands

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