Colour reaction of dichlorphenamide and related sulphonamide drugs
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A specific colour reaction for the determination of dichlorphenamide is reported. The method is based on the reaction of dichlorphenamide with an aliphatic amine,n-butylamine, and cobaltous chloride in anhydrous methanol, a blue-violet colour is produced and is measured at the wavelength of maximum absorbance at 570 nm. The developed colour is suggested to be specific for the aromatic unsubstituted sulphonamide groups, the specificity of the reaction is elucidated through application to other related sulphonamide compounds.
KeywordsPublic Health Chloride Methanol Internal Medicine Maximum Absorbance
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