Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1116–1120 | Cite as

Stability of corticosteroids under anaerobic conditions

VI. Kinetics of the decomposition of prednisolone and the appearance of some decomposition products in aqueous solution under anaerobic conditions
  • D. Dekker
  • J. H. Beijnen
Original Article


The kinetics of decomposition of prednisolone in aqueous solution were studied under anaerobic conditions at 100°C within the pH range 1.8–8.3. At pH=2.5 prednisolone is most stable. Between pH=5.0 and pH=6.0 the decomposition rate is nearly independent of the pH value. The decomposition products, 17-deoxy-21-dehydroprednisolone, 17-deoxyprednisolone, the 17-ketosteroid and the D-homosteroid were analysed quantitatively. The total amount of acidic decomposition products was approximated. Below pH=5.5 prednisolone decomposes to 17-deoxy-21-dehydroprednisolone. However, at higher pH values a mixture of decomposition products appears. All analyses were performed by a stability indicating high performance liquid Chromatographic method using uv detection.


Public Health Aqueous Solution Internal Medicine Corticosteroid Prednisolone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bundgaard, H., andJ. Hansen (1979)Arch. Pharm. Chemi Sci. Ed. 7, 19.Google Scholar
  2. Conbere, J. P., and N. J.Fanwood (1956)US patent 2, 773,077.Google Scholar
  3. Dekker, D. (1979)Pharm. Weekblad Sci. Ed. 1, 112;Ibidem (1980a)2, 14;Ibidem (1980b)2, 28;Ibidem (1980c)2, 59;Ibidem (1980d)2, 87.Google Scholar
  4. Dekker, D., andJ. H. Beijnen (1980a)J. Chromtog. 193, 480;Ibidem (1980b)Fresenius Z. Anal. Chem. in press.Google Scholar
  5. Dekker, D., andD. J. Buijs (1980)Pharm. Weekblad Sci. Ed. 2, 54.Google Scholar
  6. Duvivier, J. (1965)J. Chromatog. 19, 352.Google Scholar
  7. Guttman, D. E., andP. D. Meister (1958)J. Am. Pharm. Assoc. Sci. Ed. 47, 773.Google Scholar
  8. Hansen, J., andH. Bundgaard (1979)Arch. Pharm. Chemi Sci. Ed. 7, 135.Google Scholar
  9. Kripalani, K. J., andD. L. Sorby (1967)J. Pharm. Sci. 56, 687.Google Scholar
  10. Mason, H. L. (1938)J. Biol. Chem. 124, 475.Google Scholar
  11. Monder, C. (1968)Endocrinology 82, 318.Google Scholar
  12. Oesterling, T. O., andD. E. Guttman (1964)J. Pharm. Sci. 53, 1189.Google Scholar
  13. Wendler, N. L., and R. P.Graber (1956)Chem. and Ind. (London), 549.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • D. Dekker
    • 1
  • J. H. Beijnen
    • 1
  1. 1.Department of Analytical Pharmacy, Faculty of PharmacyState University of UtrechtGH UtrechtThe Netherlands

Personalised recommendations