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Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 853–858 | Cite as

De toepassing van theofyllinepreparaten met vertraagde afgifte

  • J. Zuidema
  • R. J. van Bever
  • F. W. H. M. Merkus
Overzichtsartikelen

Abstract

Sustained release preparations are expensive and experience with them is but little. A clear indication is needed for the application of sustained release preparations. After administration of quickly releasing preparations to patients with a rapid elimination, risk occurs for too large differences in peak and trough concentrations. Nevertheless a medication schedule of twice a day is desirable in view of the patient compliance. The application of sustained release preparations twice a day is justified for patients with an elimination half-life less than eight hours. This is generally the case with children. For adults it can be calculated that sustained release preparations are only indicated if more than 10, resp. 15 mg per kg body weight per day is needed to obtain a serum theophylline concentration of 10, resp. 15μg/ml in steady state.

Promising preparations, available on the American market, are Slophylline®, Theolair sr® and Theodur®4.

Keywords

Public Health Body Weight Internal Medicine Steady State Theophylline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • J. Zuidema
    • 1
  • R. J. van Bever
    • 2
  • F. W. H. M. Merkus
    • 1
    • 2
  1. 1.Laboratorium voor Artsenijbereidkunde der Universiteit van Amsterdamtv Amsterdam
  2. 2.R.K. Ziekenhuisbk Sittard

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