Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 825–832 | Cite as

Transport in QSAR III

The determination of transport rate constants. Method and apparatus
  • J. TH. M. van De Waterbeemd
  • A. C. A. Jansen
  • K. W. Gerritsma
Original Articles


An apparatus, with good hydrodynamic properties, and a method for the determination of transport rate constants in a two-phase system (organic solvent/water) are described.


Public Health Internal Medicine Transport Rate Hydrodynamic Property Transport Rate Constant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Albery, W. J., andJ. Hadgraft (1979)J. Pharm. Pharmacol. 31, 65.Google Scholar
  2. Ariëns, E. J. (Ed.) (1964)Mol. Pharmacol., Vol 1, Academic Press, New York.Google Scholar
  3. Armstrong, N. A., K. C. James andC. K. Wong (1979)J. Pharm. Pharmacol. 31, 657.Google Scholar
  4. Brodin, A., andA. Ågren (1971)Acta Pharm. Suec. 8, 609.Google Scholar
  5. Dasler, W., andC. D. Bauer (1946)Ind. Eng. Chem. (Anal. Ed.)18, 52.Google Scholar
  6. Doluisio, J. T., andJ. V. Swintosky (1964)J. Pharm. Sci. 53, 597.Google Scholar
  7. Franke, R. (1979)Il Farmaco, Ed. Sci. 34, 545.Google Scholar
  8. Hansch, C., andJ. M. Clayton (1973)J. Pharm. Sci. 62, 1.Google Scholar
  9. Hansch, C., andT. Fujita (1964)J. Am. Chem. Soc. 86, 1616.Google Scholar
  10. Higuchi, T., andA. F. Michaelis (1968)Anal. Chem. 40, 1925.Google Scholar
  11. Howard, S. A., M. A. Farvar, A. Suzuki andW. J. Higuchi (1969)J Pharm. Sci. 58, 1325, 1330.Google Scholar
  12. Koch, H. (1977)Österr. Apotheker Ztg. 31, 1.Google Scholar
  13. Kubinyi, H. (1976)Arzneimittel-Forsch. 26, 1991.Google Scholar
  14. Kubinyi, H. (1979)Arzneimittel-Forsch. 29, 1067.Google Scholar
  15. Leo, A., C. Hansch andD. Elkins (1971)Chem. Rev. 71, 525.Google Scholar
  16. Lippold, B. C., andG. F. Schneider (1975)ArzneimittelForsch. 25, 843.Google Scholar
  17. Mietzsch, F., J. Klarer andR. Behnisch(1943)US Patent 2, 335,599.Google Scholar
  18. Niebergall, P. J., M. Y. Patil andE. T. Sugita (1967)J. Pharm. Sci. 56, 943.Google Scholar
  19. Nitsch, W. (1965)Ber: der Bunsengesellschaft 69, 884.Google Scholar
  20. Paton, W. D. M. (1961)Proc. Roy. Soc. Ser. B 154, 21.Google Scholar
  21. Perrin, J. (1967)J. Pharm. Pharmacol, 19, 25.Google Scholar
  22. Perry, R. H., andC. H. Chilton (Eds.) (1973)Chemical Engineers Handbook, McGraw-Hill Book Company, New York.Google Scholar
  23. Rekker, R. F. (1979)II Farmaco, Ed. Sci. 34, 346.Google Scholar
  24. Robertson, J. S., andO. Bode (1970)J. Pharm. Pharmacol. 22, 423.Google Scholar
  25. Rosano, H. L., P. Duby andJ. H. Schulmann (1961).J Phys. Chem. 65, 1704.Google Scholar
  26. Schumacher, G. E., andJ. B. Nagwekar (1974)J. Pharm. Sci. 63, 240.Google Scholar
  27. Stehle, R. G., andW. I. Higuchi (1972)J. Pharm. Sci. 61, 1922.Google Scholar
  28. Stricker, H. (1970)Arzneimittel-Forsch. 20, 391.Google Scholar
  29. Ting, H. P., G. L. Bertrand andD. F. Sears (1966)Biophys. J. 6, 813.Google Scholar
  30. Waterbeemd, J. Th. M. van De, A. C. A. Jansen andK. W. Gerritsma (1978)Pharm. Weekblad 113, 1097.Google Scholar
  31. Waterbeemd, J. Th. M. van De,et al. (1980)Eur. J. Med. Chem., in press.Google Scholar
  32. Yunker, M. H., andS. Borodkin (1971)J. Pharm. Sci. 60, 52.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • J. TH. M. van De Waterbeemd
    • 1
  • A. C. A. Jansen
    • 1
  • K. W. Gerritsma
  1. 1.Department of Pharmacochemistry, Subfaculty of PharmacyUniversity of LeidenThe Netherlands

Personalised recommendations