The preservation of Lanette Wax Cream (FNA)
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Abstract
Factors influencing the free concentration methylparaben in Lanette Wax Cream (fna) were studied. These factors are the partitioning of the preservative between oil and water phase and solubilisation by the micelles of emulsifier, sodium lauryl sulphate. Solubilisation could be described as simple partitioning provided that the free concentration of methylparaben did not exceed 0.1% (w/v). The influence of propylene glycol on partitioning and solubilisation was also studied.
Microbiological studies were performed on five creams differing only in preservative system viz. 0.2% and 0.4% methylparaben, 20% propylene glycol, 0.4% methylparaben + 20% propylene glycol, and 0.15% sorbic acid. A formulation containing 0.15% sorbic acid was preferred.
Keywords
Public Health Sodium Sulphate Internal Medicine Propylene
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References
- Bean, H. S., G. H. Konning andS. A. Malcolm (1969) A model for the influence of emulsion formulation on the activity of phenolic preservatives.J. Pharm. Pharmacol. 21, Suppl. 179S-181S.Google Scholar
- Büchi, J., J. B. Hansen andS. A. Tammilehto (1971) Physikalisch-chemische Eigenschaften und antimikrobielle Wirksamkeit einiger 4-Hydroxybenzoësäureester.Pharm. Acta Helv. 46, 620–626.Google Scholar
- Doorne, H. Van (1977)Interactions between microorganisms and some components of pharmaceutical preparations, Thesis, Leiden.Google Scholar
- Doorne, H. Van (1979) De bepaling van de antimicrobiële activiteit van conserveermiddelen in farmaceutische preparaten.Pharm. Weekblad 114, 69–74.Google Scholar
- Garret, E. R. (1966) A basic model for the evaluation and prediction of preservative action.J. Pharm. Pharmacol. 18, 581–601.Google Scholar
- Hannuksela, M., V. Pirila andO. P. Solo (1975) Contact dermatitis to propylene glycol.Contact Dermatitis 1, 112–116.Google Scholar
- Jund, Y., andC. Carrère (1971) Détermination de l'activité bactériostatique et fongistatique de quelques conservateurs en présence de différents types d'excipients modernes pour pommades.Ann. Pharm. Franc. 29, 161–172.Google Scholar
- Kazmi, S. J. A., andA. G. Mitchell (1971a) Dialysis method for determining preservative distribution in emulsions.J. Pharm. Sci. 60, 1422–1424.Google Scholar
- Kazmi, S. J. A., andA. G. Mitchell (1971b) Interaction of preservatives with cetomacrogol.J. Pharm. Pharmacol. 23, 482–489.Google Scholar
- Mitchell, A. G., andS. J. A. Kazmi (1977) Chemical preservation of emulsified and solubilized disperse systems.Cosmetics and Toiletries 92, 33–43.Google Scholar
- Nederlandse Farmacopee 8th Ed. (1978), Staatsuitgeverij The Hague, 155.Google Scholar
- Patel, N. K., andJ. M. Romanowski (1970) Heterogeneous systems II. Influence of partitioning and molecular interactions in vitro biologic activity of preservatives in emulsions.J. Pharm. Sci. 59, 372–376.Google Scholar
- Poprzan, J., andM. G. De Navarre (1959). The interference of non-ionic emulsifier with preservatives VIII.J. Soc. Cosmetic Chemists 10, 81–87.Google Scholar
- Prickett, P. S., H. L. Murray andN. H. Mercer (1961) Potentiation of preservatives (parabens) in pharmaceutical formulations by low concentrations of propylene glycol.J. Pharm. Sci. 50, 316–320.Google Scholar
- Rae, J. (1938) The preservative properties of ethylene and propylene glycol.Pharm. J. 140, 517.Google Scholar
- Shore, R. N., andW. B. Shelley (1974) Contact dermatitis from stearylalcohol and propylene glycol in fluocinolide cream.Arch. Dermatol. 109, 397–399.Google Scholar
- Wedderburn, D. L. (1964)Preservation of emulsions against microbial attack. In:H. S. Bean, H. Beckett andJ. E. Carless (Eds). Advances in Pharmaceutical Sciences. Academic Press, London, 195–268.Google Scholar
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© Bohn, Scheltema & Holkema 1980