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Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 170–181 | Cite as

Microbiologische contaminatie tijdens de bereiding van parenteralia

  • F. A. Boom
Parenteralia

Samenvatting

Aan de hand van de produktie van infusievloeistoffen in onze ziekenhuisapotheek zullen de microbiologische contaminatiebronnen worden besproken, die tijdens de bereiding het produkt kunnen besmetten. Tevens zullen enkele onderzoekmethoden worden besproken, waarmee contaminatiebronnen opgespoord en gekwantificeerd kunnen worden. Uit onze waarnemingen blijkt dat het, bij gebruik van micro-organismen-arm water, een microorganismen-arm leidingensysteem, een bubblepoint getest membraanfilter van 0,45 of 0,2μm, micro-organismen-arme verpakkingsmaterialen en een werkwijze van het personeel waarbij direct contact met de oplossing en de verpakkingsmaterialen wordt vermeden, goed mogelijk is infusievloeistof met maximaal 10 micro-organismen per ml te bereiden.

Microbiological contamination during the production of parenterals

Abstract

In this article sources of microbiological contamination of infusion fluids, produced in a hospital pharmacy, are discussed. These sources may contaminate the fluids during production. Some test methods that allow us to detect and quantify these sources are also discussed. Our experience shows that it is possible to produce infusion fluids containing a maximum of 10 micro-organisms pro ml. This requires the use of water, pipes and packing materials that are poor in micro-organisms, and of a bubblepoint tested membrane filter of 0.45 or o.2 μm. Direct contact with the solution and the packing material by the staff should be avoided by an adequate working method.

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Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • F. A. Boom
    • 1
  1. 1.Apotheek SlotervaartziekenhuisAmsterdam

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