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Pharmaceutisch Weekblad

, Volume 10, Issue 6, pp 277–280 | Cite as

Screening of some essential oils for their activities on dermatophytes

  • A. M. Janssen
  • J. J. C. Scheffer
  • A. W. Parhan-Van Atten
  • A. Baerheim Svendsen
Original Articles

Abstract

Fifty-three essential oils were tested against three frequently occurring dermatophytes (Epidermophyton floccosum, Trichophyton mentagrophytes var.interdigitale, T. rubrum) by means of an agar dilution technique. The oils were selected at random and not on the basis of a supposed activity. A number of oils showed interesting activities, expressed as maximum inhibitory dilution values, against the dermatophytes used. At the highest dilution tested (1:3,200, vol/vol), one out of six oils was active againstT. mentagrophytes var.interdigitale, and one out of three to four oils was active against the other dermatophytes.

Keywords

Agar dilution technique Antimycotics Dermatophytes Drug screening Essential oils Statistics 

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References

  1. 1.
    Janssen AM, Chin NLJ, Scheffer JJC, Baerheim Svendsen A. Screening for antimicrobial activity of some essential oils by the agar overlay technique. Statistics and correlations. Pharm Weekbl [Sci] 1986;8:289–92.Google Scholar
  2. 2.
    Botter AA. Dermatophytic infections and their treatment. J Drug Ther Res 1984;9:357–63.Google Scholar
  3. 3.
    Manten A. Antimycotica. In: Lammers W, Nelemans FA, Bouwman ThJ, Van Noordwijk J, Rosinga WM, eds. Algemene farmacotherapie. Het geneesmiddel in theorie en praktijk. 3rd ed. Leiden: Stafleu's Wetenschappelijke Uitgeversmaatschappij, 1975:214–20.Google Scholar
  4. 4.
    Klokke AH. Spectrum of human mycoses. J Drug Ther Res 1984;9:328–9.Google Scholar
  5. 5.
    Samson R. Biology of pathogen fungi. J Drug Ther Res 1984;9:347–51.Google Scholar
  6. 6.
    Weinberg ED. Antifungal agents. In: Wolff ME, ed. Burger's medicinal chemistry. 4th ed. Part 11. Chichester: John Wiley & Sons, 1979:531–41.Google Scholar
  7. 7.
    Van Bronswijk JEMH. Laboratory diagnostics of fungal skin diseases. J Drug Ther Res 1984;9:353–6.Google Scholar
  8. 8.
    Funder S. Practical mycology. Oslo: Brøggers Boktr. Forlag, 1953:77–90.Google Scholar
  9. 9.
    Wade A, ed. Martindale. The Extra Pharmacopoeia. 27th ed. London: The Pharmaceutical Press, 1977: 635.Google Scholar
  10. 10.
    Van Joost Th, Stolz E, Van der Hoek JCS, Clermonts E. Sensitization to perfume-compounds: clinical and statistical studies. J Drug Ther Res 1984;9:303–5.Google Scholar
  11. 11.
    Bronaugh RL, Stewart RF, Wester RC, Bucks D, Maibach HI, Anderson J. Comparison of percutaneous absorption of fragrances by humans and monkeys. Food Chem Toxicol 1985;23:111–4.PubMedGoogle Scholar
  12. 12.
    Abramovici A, Rachmuth-Roizman P. Molecular structure-teratogenicity relationships of some fragrance additives. Toxicology 1983;29:143–56.PubMedGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1988

Authors and Affiliations

  • A. M. Janssen
    • 1
  • J. J. C. Scheffer
    • 1
  • A. W. Parhan-Van Atten
    • 1
  • A. Baerheim Svendsen
    • 1
  1. 1.Division of Pharmacognosy, Center for Bio-Pharmaceutical SciencesLeiden University, Gorlaeus LaboratoriesRA Leidenthe Netherlands

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