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Pharmaceutisch Weekblad

, Volume 10, Issue 6, pp 254–258 | Cite as

Sublingual nitroglycerin

II. In vitro and in vivo availability of Nitrostat® and Nitrobaat® tablets
  • M. Lagas
  • A. M. J. A. Duchateau
Original Articles

Abstract

Thein vitro andin vivo availability of nitroglycerin from three compressed and one stabilized molded tablet have been studied. Compressed nitroglycerin tablets have to disintegrate before the drug is released. The disintegration and release of nitroglycerin from these tablets appeared to be strongly dependent upon conditions in thein vitro dissolution tests, such as the degree of agitation, andin vivo factors, such as tongue pressure and/or movement. The stabilized molded nitroglycerin tablet did not disintegrate but dissolved completely. Because the dissolution of the molded tablet was fast, the release rate of nitroglycerin was far less influenced by thein vitro andin vivo factors described above. The potency andin vitro andin vivo availability of fresh tablets and tablets which had been stored in tightly closed glass containers for over one year did not differ significantly. It is conjectured that the supposed potency loss of properly stored compressed nitroglycerin tablets is rather a release problem than a stability problem.

Keywords

Administration, sublingual Biological availability Disintegration Dissolution Drug compounding Glyceryl trinitrate Tablets 

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References

  1. 1.
    Lagas M, Duchateau AMJA. Sublingual nitroglycerin. I. Comparative evaluation of the physical stability of commercially available tablets. Pharm Weekbl [Sci] 1988;10:246–53.Google Scholar
  2. 2.
    Noonan PK, Benet LZ. Incomplete and delayed bio-availability of sublingual nitroglycerin. Am J Cardiol 1985;55:184–7.PubMedGoogle Scholar
  3. 3.
    Langenbucher F, Rettig H. Dissolution rate testing with the column method: methodology and results. Drug Devel Ind Pharm 1977;3(3):241–63.Google Scholar
  4. 4.
    Möller H. Dissolution testing of different dosage forms using the flow-through method. Pharm Ind 1983;6:617–22.Google Scholar
  5. 5.
    Koch HP. Die Technik der Dissolutionsbestimmung. Pharm Acta Helv 1984;59:98–105.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1988

Authors and Affiliations

  • M. Lagas
    • 1
  • A. M. J. A. Duchateau
    • 2
  1. 1.Laboratory for Pharmaceutical ResearchSH Rodenthe Netherlands
  2. 2.Central Hospital Pharmacy 's-HertogenboschJL 's-Hertogenboschthe Netherlands

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