HPLC-analysis and preliminary pharmacokinetic parameter estimations of chloroquine
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AnHplc method for the separate determination of chloroquine and its major metabolites has been developed. Separation was on an octadecylRp column. Fluorimetric detection followed after on-line post-column buffering of the mobile phase to pH=9.25. The method is highly selective for the compounds of interest with a detection limit down to 1 ng/ml. Preliminary data on the pharmacokinetics of chloroquine are reported, as obtained with this method. Kinetic parameters were estimated with the aid of the non-linear regression computer programmeNonlin.
KeywordsMalaria Chloroquine Labetalol Quine Fluorimetric Detection
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