The influence of glutathione on the photoreaction of 3,4′,5-tribromosalicyl-anilide alone and in the presence of serum albumin
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Glutathione is known to play a prominent detoxifying role in the organism. In this study attention has been paid to the possible occurrence of a detoxifying action of glutathione in the skin. For this reason we studied the influence of glutathione on the photoreaction of 3,4′,5-tribromosalicylanilide (Tbsa), which is notorious for causing photoallergy. It was found thatTbsa forms stable photoconjugates on irradiation with glutathione: 3-glutathyl-4′,5-dibromosalicylanilide and 5-glutathyl-4′-bromosalicylanilide. The rate of the photoreaction ofTbsa in the presence of glutathione, resulting in photostable products, is increased. Furthermore, covalent binding with serum albumin appeared to be decreased in the presence of glutathione.
KeywordsGlutathione High Pressure Liquid Chromatography Covalent Binding Anilide Sulfamides
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