Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 1560–1563 | Cite as

The influence of emulsifiers on drug diffusion from o/w creams

  • C. Provost
  • R. Kinget
  • H. Herbots
Original Articles


Histamine diffusion from various o/w creams containing different emulsifiers was studied. To confirm the diffusion study, possible drug-emulsifier interactions were studied by dialysis of their aqueous solutions. Interaction between histamine and anionic sodium laurylsulphate resulted in the absence of free diffusible histamine. No interaction was observed with the non-ionic cetomacrogol. Repulsion by the cationic cetrimide increased histamine diffusion rate and total diffusing amount because distribution occurred in accordance with the Donnan membrane equilibrium.


Histamine Sodium Laurylsulphate Methylparaben Cetrimide Sodium Stearate 
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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • C. Provost
    • 1
  • R. Kinget
    • 1
  • H. Herbots
    • 1
  1. 1.Dept. of PharmaceuticsCatholic University of LeuvenLeuvenBelgium

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