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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 1285–1301 | Cite as

Radiopharmaceuticals and good radiopharmacy practice

  • M. G. Woldring
Review Articles

Abstract

Good Manufacturing Practice (GMP) is concerned with both manufacturing and quality control procedures. Good radiopharmacy practice means GMP applied to radiopharmaceuticals by taking into account the special nature of these products. Because radioactive substances are the essential basis for the acquisition of data from nuclear medicine investigations, attention has to be paid to the control of all parameters of quality assurance. This is particularly important in those cases where quality control tests have to be performed on apost factum basis,i.e. after administration to the patient, because of the short half-life time of the radionuclide.

Radiopharmaceutical quality control is a necessity in all nuclear medicine departments. If a laboratory does not institute radiopharmaceutical quality control until the cause of a ‘poor image’ in the diagnostic process must be identified, the problem will be compounded. The quality control tests must be mastered before they can be used to resolve problems.

Keywords

Technetium Pertechnetate Good Manufacture Practice Quality Control Test Isomeric Transition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Selected reading

  1. Bett, R.,et al. (1981)Nucl. Med. Comm. 2, 75–79.CrossRefGoogle Scholar
  2. Frier, M., andS.R. Hesslewood (1980)Quality Assurance of Radiopharmaceuticals. Chapman and Hall Ltd, London.Google Scholar
  3. GonÇalves Rocha, A.F., andJ.C. Harbert (1978)Textbook of Nuclear Medicine: Basic Science. Lea & Febiger, Philadelphia.Google Scholar
  4. Heindel, N.D.,et al. (1978)The Chemistry of Radiopharmaceuticals. Masson Publishing Inc., New York.Google Scholar
  5. Kristensen, K. (1979)IAEA Technical Report Series no. 194.Google Scholar
  6. Phan, T.T., andR. Wasnich (1981)Practical Nuclear Pharmacy. Banyan Enterprises, Honolulu.Google Scholar
  7. Rhodes, B.A., andB.Y. Croft (1978)Basics of Radiopharmacy. The C.V. Mosby Company, Saint Louis.Google Scholar
  8. Saha, G.B. (1979)Fundamentals of Nuclear Pharmacy. Springer-Verlag, Inc., New York.CrossRefGoogle Scholar
  9. Subramanian, G.,et al. (1975)Radiopharmaceuticals. Society of Nuclear Medicine, Inc., New York.Google Scholar
  10. Welch, M.J. (1977)Radiopharmaceuticals and Other Compounds Labelled with Short-lived Radionuclides. Pergamon Press Ltd., New York.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • M. G. Woldring
    • 1
  1. 1.Department of Nuclear MedicineUniversity HospitalEZ GroningenThe Netherlands

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