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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 1187–1191 | Cite as

South American ritual Anadenanthera enemas

  • P. A. G. M. De Smet
Wetenschappelijke Mededelingen

Abstract

Certain differences between the native and experimental administration of hallucinogens, such as another route of administration, should not be disregarded. To set an example, the ritual use ofAnadenanthera enemas by South American Indians is discussed. In pharmacological studiesAnadenanthera alkaloids have been found to produce the alleged effects of these dosage forms. However, in contrast with dimethyltryptamine and its 5-methoxyderivative, bufotenine is likely to have no or only a weak central activity. Up to now oral administration has not been demonstrated to be effective, although relatively large doses have been studied. As first-pass metabolism is a likely cause of this inactivity, it cannot be safely assumed that rectal administration will give better results than oral administration.

Samenvatting

Bepaalde verschillen tussen de inheemse en experimentele toediening van hallucinogenen, zoals een andere toedieningsweg, mogen niet worden veronachtzaamd. Om een voorbeeld te geven wordt het rituele gebruik vanAnadenanthera klysma's door Zuidamerikaanse indianen besproken. In farmacologische onderzoekingen hebbenAnadenanthera-alkaloïden de werking die aan deze toedieningsvormen wordt toegeschreven. Het is evenwel aannemelijk dat bufotenine, in tegenstelling tot dimethyltryptamine en het 5-methoxyderivaat daarvan, geen of een slechts zwakke centrale werking heeft. Tot dusverre is niet aangetoond dat orale toediening effectief is, hoewel relatief hoge doses zijn onderzocht. Aangezien ‘first-pass’ metabolisme een aannemelijke oorzaak hiervan is, kan niet veilig worden aangenomen dat rectale toediening betere resultaten zal geven dan orale toediening.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • P. A. G. M. De Smet
    • 1
  1. 1.Documentatie- en Informatiedienst KNMPJL The Hague

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