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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 1085–1089 | Cite as

Analysis of thyroid and thyroxin by means of high performance liquid chromatography

  • P. J. J. De Meijer
Laboratorium der Nederlandse Apothekers

Abstract

This paper presents a high performance liquid Chromatographic method to analyse thyroxin containing formulations. The same method can be used to analyse the liothyronin and thyroxin content of hydrolyzed thyroid raw material. The proposed method can be used as content uniformity test. An interaction is noticed between thyroxin and lactose in the presence of ammonia. The method is suitable for routine analysis.

Samenvatting

Een HPLC-methode voor de analyse van thyroxinebevattende preparaten wordt beschreven. Deze methode kan ook worden gebruikt om het gehalte aan liothyronine en thyroxine in gehydrolyseerde thyreoïde-grondstof te bepalen. De voorgestelde methode is bruikbaar als controle op de gelijkmatigheid van gehalte. Een interactie tussen thyroxine en lactose werd vastgesteld bij aanwezigheid van ammonia. De methode is geschikt voor routine-analyse.

Keywords

High Performance Liquid Chromatography Lactose Thyroxin Liothyronin Internal Standard Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • P. J. J. De Meijer
    • 1
  1. 1.Laboratorium der Nederlandse ApothekersJL ∫-Gravenhage

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