Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 822–825 | Cite as

Effect of chloroquine on hepatic triacylglycerol metabolism

  • A. C. Beynen
  • A. J. Van Der Molen
  • M. J. H. Geelen
Short Communications


Chloroquine, a lysosomotropic agent, has been found to be a potent inhibitor of hydrolysis of triacylglycerol stores in isolated hepatocytes from starved donor rats. It significantly inhibits the disappearance of radioactivity from prelabelled triacylglycerols and the appearance of label in acid-soluble products. Furthermore, it inhibits oxidation and stimulates esterification of added oleate.


Oleate Chloroquine Fatty Acid Oxidation Triacylglycerol Lipase Pharmaceutisch Weekblad Scientific Edition 
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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • A. C. Beynen
    • 1
  • A. J. Van Der Molen
    • 1
  • M. J. H. Geelen
    • 1
  1. 1.Laboratory of Veterinary BiochemistryState University of UtrechtBP UtrechtThe Netherlands

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