Inhibition of cholesterol synthesis in isolated rat hepatocytes by salicylate
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Salicylate has been found to be an inhibitor of cholesterol biosynthesis by isolated hepatocytes. Half maximal inhibition of cholesterogenesis occurs at approximately 7.5 mmol/l salicylate. It is proposed that salicylate, at blood levels encountered therapeutically, inhibits hepatic cholesterol synthesis.
KeywordsSalicylate Chloroquine Cholesterol Synthesis Rheumatic Fever Sodium Salicylate
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