Advertisement

Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 815–819 | Cite as

The effect of 2,4,6-triaminopyrimidine on increased mucosal permeability of guinea-pig colonic mucosa, following administration of 1,8-dihydroxyanthraquinone, salicylic acid and dinitrophenol

  • E. H. C. Verhaeren
  • A. M. Verbruggen
  • J. A. J. M. Lemli
Article

Abstract

Administration of 1,8-dihydroxyanthraquinone to guinea-pigs increases colonic permeability. The transfer of99mTc-labelled EDTA from mucosa to serosa was markedly increasedin vivo. In one hour 25% of the administered radioactive compound leaked out of the colon to concentrate in the urine. A similar enhanced complex transfer was observed following administration of salicylic acid and dinitrophenol (DNP), respectively 14% and 12%. The increased permeability could be restored to nearly normal values after 2,4,6-triaminopyrimidine (TAP) injection in the colon segment.

Keywords

Salicylic Acid Anthraquinone Dinitrophenol Colon Segment Methyl Ethyl Ketone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arvanitakis, C., G. H. Chen, J. Folscroft andN. J. Greenberger (1977)Gut 18, 187–190.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Brody, T. M. (1972)J. Pharmacol. Exp. Therap. 117, 39–51.Google Scholar
  3. Clarkson, T. W. (1967)J. Gen. Physiol. 50, 695–727.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Eckelman, W., andP. Richards (1970)J. Nucl. Med. 11, 761.PubMedGoogle Scholar
  5. Fuhro, R., andD. Fromm (1978)Gastroenterol. 75, 661–667.Google Scholar
  6. Frömter, E. (1972)J. Membr. Biol. 8, 259–301.CrossRefPubMedGoogle Scholar
  7. Frömter, E., andJ. H. Diamond (1972)Nature Biol. 235, 9–13.CrossRefGoogle Scholar
  8. Hoshi, T., andE. Sakai (1967)Japan. J. Physiol. 17, 627–637.CrossRefGoogle Scholar
  9. Lindberg, A. (1957)Acta Physiol. Scand. 40, 35–58.CrossRefGoogle Scholar
  10. Machen, T. E., D. Erly andE. B. P. Wooding (1972)J. Cell Biol. 54, 302–312.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Martinez-Palomo, A., andD. Erly (1973)D. Pflügers Arch. 343, 267–284.CrossRefGoogle Scholar
  12. Moreno, J. (1975a)J. Gen. Physiol. 66, 97–115;Ibidem (1975b)66, 117–128.CrossRefPubMedGoogle Scholar
  13. Nell, G., W. Forth, W. Rummel andR. Wanitschke (1976)Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 293, 31–37.CrossRefGoogle Scholar
  14. Nell, G., W. Rummel andR. Wanitschke (1977)Intestinal Permeation, Vol. 40. Excerpta Medica, Amsterdam-Oxford, 413–419.Google Scholar
  15. Persson, B. (1975)Radiopharmaceutics. The Society of Nuclear Medicine, New York, 228–235.Google Scholar
  16. Rose, R. C., andS. G. Schultz (1971)J. Gen. Physiol. 57, 639–663.CrossRefPubMedPubMedCentralGoogle Scholar
  17. Schultz, S. G., R. Frizzell andS. H. N. Nellon (1974)Ann. Rev. Physiol. 36, 51–91.CrossRefGoogle Scholar
  18. Spenney, J. G., andM. Brown (1977)Gastroenterol. 73, 995–999.Google Scholar
  19. Tischer, C. C., andW. E. Yarger (1973)Kidney Interat. 3, 238–250.CrossRefGoogle Scholar
  20. Ussing, H. H., andE. E. Windhager (1964)Acta Physiol. Scand. 61, 484–504.PubMedGoogle Scholar
  21. Ussing, H. H., D. Erly andV. Lassen (1974)Ann. Rev. Physiol. 36, 17–49.CrossRefGoogle Scholar
  22. Verhaeren, E. (1980a)Phytochemistry 19, 501–503;Ibidem (1980b)Pharmacology 20, Suppl. 1, 43–49.CrossRefGoogle Scholar
  23. Windhager, E. E., E. L. Boulpaep andG. Giebisch (1966)Proc. 3rd. Int. Congr. Nephrol. 1, 35.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • E. H. C. Verhaeren
    • 1
  • A. M. Verbruggen
    • 2
  • J. A. J. M. Lemli
    • 1
  1. 1.Laboratory of PharmacognosyInstitute of Pharmaceutical Sciences, Catholic University of LeuvenLeuvenBelgium
  2. 2.Laboratory of Radiopharmacy, Department of Nuclear MedicineCatholic University of LeuvenLeuvenBelgium

Personalised recommendations