Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 815–819 | Cite as

The effect of 2,4,6-triaminopyrimidine on increased mucosal permeability of guinea-pig colonic mucosa, following administration of 1,8-dihydroxyanthraquinone, salicylic acid and dinitrophenol

  • E. H. C. Verhaeren
  • A. M. Verbruggen
  • J. A. J. M. Lemli


Administration of 1,8-dihydroxyanthraquinone to guinea-pigs increases colonic permeability. The transfer of99mTc-labelled EDTA from mucosa to serosa was markedly increasedin vivo. In one hour 25% of the administered radioactive compound leaked out of the colon to concentrate in the urine. A similar enhanced complex transfer was observed following administration of salicylic acid and dinitrophenol (DNP), respectively 14% and 12%. The increased permeability could be restored to nearly normal values after 2,4,6-triaminopyrimidine (TAP) injection in the colon segment.


Salicylic Acid Anthraquinone Dinitrophenol Colon Segment Methyl Ethyl Ketone 
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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • E. H. C. Verhaeren
    • 1
  • A. M. Verbruggen
    • 2
  • J. A. J. M. Lemli
    • 1
  1. 1.Laboratory of PharmacognosyInstitute of Pharmaceutical Sciences, Catholic University of LeuvenLeuvenBelgium
  2. 2.Laboratory of Radiopharmacy, Department of Nuclear MedicineCatholic University of LeuvenLeuvenBelgium

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