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Pharmaceutisch weekblad

, Volume 3, Issue 1, pp 224–237 | Cite as

Transport in QSAR IV

The interfacial drug transfer model. Relationships between partition coefficients and rate constants of drug partitioning
  • J. Th. M. Van De Waterbeemd
  • C. C. A. A. Van Boekel
  • R. L. F. M. De Sévaux
  • A. C. A. Jansen
  • K. W. Gerritsma
Original Articles

Abstract

A model for the interphase transfer of drugs is developed and theoretical relationships between partition coefficients and partitioning (transport) rate constants are derived.

A good agreement with experimental data from a series of sulfonamide derivatives is obtained. It is concluded that stagnant diffusion layers at the interface determine to a large extent the transfer rate constants.

Keywords

Homologous Series Gibbs Free Energy Diffusion Rate Constant Bilinear Equation Pharmaceutisch Weekblad Scientific Edition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1981

Authors and Affiliations

  • J. Th. M. Van De Waterbeemd
    • 1
  • C. C. A. A. Van Boekel
    • 1
  • R. L. F. M. De Sévaux
    • 1
  • A. C. A. Jansen
    • 1
  • K. W. Gerritsma
  1. 1.Department of Pharmacochemistry, Subfaculty of PharmacyUniversity of LeidenThe Netherlands

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