Pharmacy World and Science

, Volume 15, Issue 3, pp 139–144 | Cite as

Effect of pH on absorption of sufentanil citrate in a portable pump reservoir during storage and administration under simulated epidural conditions

  • P. J. Roos
  • J. H. Glerum
  • J. W. Meilink
  • L. Zwang
Practice/Case Reports


Sufentanil (5μg/ml as citrate) was investigated for its stability when diluted with sodium chloride 0.9%, in 100 ml polyvinyl chloride portable pump reservoirs during administration under simulated epidural conditions at 32°C for 48 h. Sufentanil was absorbed into the polyvinyl chloride, resulting in a reduction of 10.9% of the concentration after 48 h. The absorption of sufentanil (5μg/ml as citrate), alone and in combination with bupivacaine hydrochloride (2 mg/ml), was investigated when diluted with sodium chloride 0.9% in combination with a citrate buffer (pH 4.6), in the same reservoirs under similar conditions. There was no loss of sufentanil after 48 h in both experiments. The effect of the pH on the absorption of sufentanil in polyvinyl chloride was investigated at different pH values. After storage for 21 days at 32°C there was 5.1% loss of sufentanil at pH 4 and 80.6% loss at pH 6. The citrate buffer at the optimum pH (4.6) has a low, acceptable buffer capacity for epidural administration.


Absorption Buffer capacity Epidural administration Polyvinyl chloride Stability Storage Sufentanil 


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  1. 1.
    Kowaluk EA, Roberts MS, Polack AE. Interactions between drugs and intravenous delivery systems. Am J Hosp Pharm 1982;39:460–7.PubMedGoogle Scholar
  2. 2.
    Roos PJ, Glerum JH, Meilink JW. Stability of morphine hydrochloride in a portable pump reservoir. Pharm Weekbl [Sci] 1992;14(1):23–6.Google Scholar
  3. 3.
    Stiles ML, Tu Y, Allen LV. Stability of morphine sulfate in portable pump reservoirs during storage and simulated administration. Am J Hosp Pharm 1989;46:1404–7.PubMedGoogle Scholar
  4. 4.
    Lohman JJHM, Janssen MJ, Cilissen J, Hendriks MWG, Hooymans PM. Compatibility of morphine HCl and bupivacaine HCl in a portable pump reservoir [abstract]. Pharm Weekbl [Sci] 1992;14(Suppl F):F27.Google Scholar
  5. 5.
    Tu Y, Stiles ML, Allen LV. Stability of fentanyl citrate and bupivacaine hydrochloride in portable pump reservoirs. Am J Hosp Pharm 1990;47:2037–40.PubMedGoogle Scholar
  6. 6.
    Dawson PJ, Bjorksten AR, Duncan IP, Barnes RK, Beemer GH. Stability of fentanyl, bupivacaine and adrenaline solutions for extradural infusion. Br J Anaesth 1992;68:414–7.PubMedGoogle Scholar
  7. 7.
    Denson DD, Crews JC, Grummich KW. Stability of methadone hydrochloride in 0.9% sodium chloride injection in single-dose plastic containers. Am J Hosp Pharm 1991;48:515–7.PubMedGoogle Scholar
  8. 8.
    Kleinberg ML, Duafala ME. Stability of heroin hydrochloride in infusion devices and containers for intravenous administration. Am J Hosp Pharm 1990;47:377–81.PubMedGoogle Scholar
  9. 9.
    Roos PJ, Glerum JH, Meilink JW. Stability of sufentanil citrate in a portable pump reservoir, a glass container and a polyethylene container. Pharm Weekbl [Sci] 1992;14(4):196–200.Google Scholar
  10. 10.
    Akerman B, Arwestrom E, Post C. Local anesthetics potentiate spinal morphine antinociception. Anesth Analg 1988; 67:943–8.PubMedGoogle Scholar
  11. 11.
    Phillips GH. Combined epidural sufentanil and bupivacaine for labor analgesia. Reg Anesth 1987;12(4):165–8.Google Scholar
  12. 12.
    Vertommen JD, Vandermeulen E, Van Aken H, Vaes L. The effects of the addition of sufentanil to 0.125% bupivacaine on the quality of analgesia during labor and on the incidence of instrumental deliveries. Anesthesiology 1991;74:809–14.PubMedGoogle Scholar
  13. 13.
    Ziegenmeyer J. Biopharmazeutische Aspekte bei der Anwendung von Dermatika. In: Niedner R, ed. Dermatika. Stuttgart: Wissenschaftliche Verlagsgesellschaft, 1992: 300–1.Google Scholar
  14. 14.
    Netherlands Pharmacopoeia. 9th ed. The Hague: Staatsuitgeverij, 1983.Google Scholar
  15. 15.
    De Vogel EM, Hendrix MMP, Van Dellen PT, Vree PH. Absorption of sufentanil on bacterial filters. Ziekenhuisfarmacie 1991;7:65–70.Google Scholar
  16. 16.
    Van der Meer YG, Van Loenen AC. Epidurale toediening van geneesmiddelen: een overzicht [Epidural administration of drugs: a review]. Pharm Weekbl 1982;117:1209–20.Google Scholar
  17. 17.
    Roos PJ, Rutgers MJ, Dirksen R, Coolen JMW. Some notes on perispinal drug administration. Pharm Weekbl 1986;121:29–32.Google Scholar
  18. 18.
    Mueller H, Boerner U, Hempelmann G. Tissue and cerebrospinal fluid tolerance of epidural opiate application. In: Cools AR, Nijhuis GMM, ed. Analgesia by peridural and spinal opiates. Oss: Nourypharma, 1980:172–87.Google Scholar
  19. 19.
    Stark P, Nolte H. pH des Liquor Spinalis während subduraler Blockade. Reg Anesth 1978;3(1):41–3.Google Scholar

Copyright information

© Royal Dutch Association for the Advancement of Pharmacy 1993

Authors and Affiliations

  • P. J. Roos
    • 1
  • J. H. Glerum
    • 2
    • 3
  • J. W. Meilink
    • 4
  • L. Zwang
    • 5
  1. 1.Department of PharmacyAcademic Medical CentreAZ Amsterdamthe Netherlands
  2. 2.Department of PharmacyUniversity Hospital UtrechtCX Utrechtthe Netherlands
  3. 3.Department of Pharmaceutics, Faculty of PharmacyUniversity of UtrechtCA Utrechtthe Netherlands
  4. 4.Department of PharmacyUniversity Hospital Rotterdam-DijkzigtGD Rotterdamthe Netherlands
  5. 5.Department of Clinical ChemistryUniversity Hospital Rotterdam-Dijkzigtthe Netherlands

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