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Pharmaceutisch Weekblad

, Volume 4, Issue 1, pp 16–20 | Cite as

Analysis of creams

II. Quantitative determination of drugs in creams by titration in non-aqueous solvents
  • F. J. Van De Vaart
  • A. Hulshoff
  • A. W. M. Indemans
Original Articles

Abstract

The possibilities for the determination of active components in creams by acid-base titrations in non-aqueous solvents were investigated. Interference by cream-base components with the titration of weak organic bases and their halides with perchloric acid in acetic acid, and with the titration of weak acids with tetrabutylammonium hydroxide in N,N-dimethylformamide were studied. It appeared to be possible to determine alkaloid halides, salicylic acid, hexachlorophene and methyl salicylate without previous clean-up of the cream samples.

Keywords

Methyl Acetic Acid Hydroxide Salicylic Acid Alkaloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. British Pharmacopoeia (1980).Google Scholar
  2. United States Pharmacopoeia XX (1980).Google Scholar
  3. Vaart, F.J. van de, A. Hulshoff andA.W.M. Indemans (1980a)Pharm. Weekbl. 115, 1429–1438;Ibidem (1980b)Pharm. Weekbl. Sci. Ed. 2, 179–185.Google Scholar
  4. Viola, M.R., A.M. Alboini, C. Canestrini andG. Donelli (1971)Boll. Chim. Farm. 110, 349–352.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • F. J. Van De Vaart
    • 1
  • A. Hulshoff
    • 2
  • A. W. M. Indemans
    • 1
    • 2
  1. 1.Laboratory of the Dutch PharmacistsJL The HagueThe Netherlands
  2. 2.Pharmaceutical Laboratory, Department of Analytical PharmacyUniversity of UtrechtGH UtrechtThe Netherlands

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