Pharmaceutisch Weekblad

, Volume 4, Issue 1, pp 1–4 | Cite as

Org-NC45: a new steroidal non-depolarizing muscle relaxant

  • L. H. D. J. Booij
  • T. B. Vree
  • J. F. Crul
Review Articles


Although pancuronium has fewest side effects compared to other currently used non-depolarizing muscle relaxants, it is still not the ideal relaxant. Its structural analogues have been studied to derive such an ideal relaxant. Org-Nc45 meets the requirements for such a relaxant best and is therefore extensively studied. It is more potent than pancuronium, has a shorter onset and duration of action and is free from cardiovascular side effects. Histamine release could not be demonstrated. It can be easily reversed by neostigmine, pyridostigmine or 4-aminopyridine. Interaction with antibiotics and anaesthetic drugs is not different from that of pancuronium.


Public Health Internal Medicine Histamine Muscle Relaxant Structural Analogue 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • L. H. D. J. Booij
    • 1
  • T. B. Vree
    • 1
  • J. F. Crul
    • 1
  1. 1.Department of AnaesthesiologySt. Radboud hospitalNijmegenThe Netherlands

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