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Pharmaceutisch Weekblad

, Volume 7, Issue 2, pp 79–82 | Cite as

Colorimetric analysis of some diuretic drugs: hydrochlorothiazide and spironolactone

  • Bahia A. Moussa
  • Naglaa M. el Kousy
Short Communications

Abstract

Two convenient spectrophotometric methods were developed for the determination of hydrochlorothiazide and spironolactone. A specific colour reaction for the determination of hydrochlorothiazide is reported. One method is based on the reaction of hydrochlorothiazide withn-butylamine and cobaltous chloride in anhydrous methanol. A blue-violet colour is produced and is measured at 570 nm. A highly selective colorimetric method was adopted for the analysis of spironolactone by reacting with isoniazid forming a coloured hydrazone derivative and subsequent measurement of the coloured product at 405 nm.

Keywords

Public Health Chloride Methanol Internal Medicine Isoniazid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1985

Authors and Affiliations

  • Bahia A. Moussa
    • 1
  • Naglaa M. el Kousy
    • 2
  1. 1.Pharmaceutical Chemistry Department, Faculty of PharmacyCairo UniversityCairoEgypt
  2. 2.National Organization of Drug Control and ResearchCairoEgypt

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