Research in the Division of Pharmaceutical Technology
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Within the Center for Bio-Pharmaceutical Sciences the release characteristics of drugs form the major research object of the Division of Pharmaceutical Technology. Transdermal systems are being developed that can supply a drug during several days. Irritation of the skin may be avoided by using hydrogels. To enable long-term transdermal application also the colloidal structure of creams and ointments is investigated. As most drugs are to be taken orally, however, a research project was also started to make cheap and easy to produce controlled release tablets. The results with a microporous polypropylene polymer are promising.
KeywordsPublic Health Polymer Internal Medicine Polypropylene Control Release
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- 1.Shaw JE. Transdermal Therapeutic Systems. In: Brandau R. Lippold BH, eds. Stuttgart: Wissenschaftliche Verlagsgesellschaft, 1982:171.Google Scholar
- 2.Hurkmans JFGM, Boddé HE, Driel LMF, Van Doorne H, Junginger HE. Skin Irritation Caused by Transdermal Drug Delivery Systems During Longterm (5 Days) Application. J Br Dermatol (in press).Google Scholar
- 3.Junginger HE. Colloidal Structures in Creams. Pharm Weekbl [Sci] 1984;6:141–9.Google Scholar
- 4.De Vringer T, Joosten JHG, Junginger HE. Characterization of the gel structure in a non-ionic ointment by small angle X-ray diffraction. Coll Polym Sci 1984;262:56–60.Google Scholar
- 5.Junginger HE, Verhoeven J, De Boer AG. Controlled release of drugs with microporous polymers. Proceedings of the 11th International Symposium on Controlled Release Bioactive Materials. Ft-Lauderdale, Florida, July 23–25,1984:4.Google Scholar
- 6.U.S. Pat. 4.247.498. Eur. Pat. 0.044.052.Google Scholar
- 7.Verhoeven J, De Boer AG, Junginger HE. The use of microporous polymeric powders for controlled-release drug delivery systems. In: Müller BW, ed. Controlled Drug Delivery. Stuttgart: Wissenschaftliche Verlagsgesellschaft (in press).Google Scholar