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Pharmaceutisch Weekblad

, Volume 9, Supplement 1, pp S41–S44 | Cite as

Influence of quinolones on throat- and faecal flora of healthy volunteers

  • H. G. de Vries-Hospers
  • G. W. Welling
  • D. van der Waaij
Article

Abstract

Oral and faecal flora were monitored in ten healthy volunteers who received three different oral dosages of either norfloxacin or ciprofloxacin during five consecutive days. Oral flora was not influenced by either quinolone. At the end of the five day-treatment period aerobic Gram-negative bacilli could no longer be cultured from the faecal samples of any of the volunteers. Enterococci were suppressed in some volunteers or remained present in concentrations as high as before treatment. All ciprofloxacin-treated volunteers became colonized with yeasts in their faecal samples, even during treatment with the lowest dose. As measured by total microscopic bacterial clump counts and the appearance of ß-aspartylglycine in faecal samples neither of the two quinolones appeared to decrease the colonization resistance of the digestive tract.

Key words

Ciprofloxacin Colonization resistance Faecal flora Norfloxacin 

References

  1. 1.
    Sleijfer DT, Mulder NH, de Vries-Hospers HG, et al. Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Eur J Cancer 1980;16:859–69.PubMedGoogle Scholar
  2. 2.
    Van der Waaij D, Berghuis-de Vries HM, Lekkerkerk-van der Wees JEC. Colonization resistance of the digestive tract in conventional and antibiotic treated mice. J Hyg (Camb) 1971:69:405–11.Google Scholar
  3. 3.
    Van der Waaij D. Colonization resistance of the digestive tract: clinical consequences and implications. J Antimicrob Chemother 1982:10:263–70.PubMedGoogle Scholar
  4. 4.
    Muytjens HL, van Veldhuizen GL, Welling GW, van der Ros-van der Repe J, Boerema HBJ, van der Waaij D. Selective decontamination of the digestive tract by pipemidic acid. Antimicrob Agents Chemother 1983:24:902–4.PubMedGoogle Scholar
  5. 5.
    Muytjens HL, van der Ros-van der Repe J, van Veldhuizen G. Comparative activities of ciprofloxacin (Bay 09867), norfloxacin, pipemidic acid and nalidixic acid. Antimicrob Agents Chemother 1983;24:302–4.PubMedGoogle Scholar
  6. 6.
    Chin N, Neu HC. In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new ß-lactams, aminoglycosides and trimethoprim. Antimicrob Agents Chemother 1983:24:754–63.PubMedGoogle Scholar
  7. 7.
    Fass RJ. In vitro activity of ciprofloxacin (Bay 0 9867). Antimicrob Agents Chemother 1983:24:568–74.PubMedGoogle Scholar
  8. 8.
    Eliopoulos GM, Gardella A, Moellering RC Jr. In vitro activity of ciprofloxacin, a new carboxyquinoline antimicrobial agent. Antimicrob Agents Chemother 1984:25:331–5.PubMedGoogle Scholar
  9. 9.
    Barry AL, Jones RN, Thomsberry C, Ayers LW, Gerlach EH, Sommers HM. Antibacterial activities of ciprofloxacin, norfloxacin, oxolinic acid, cinoxacin and nalidixic acid. Antimicrob Agents Chemother 1984:25:633–7.PubMedGoogle Scholar
  10. 10.
    Welling GW, Groen G. ß-Aspartylglycine, a substance unique to caecal contents of germ-free and antibiotic decontaminated animals. Biochem J 1978:175:807–12.PubMedGoogle Scholar
  11. 11.
    Welling GW. Comparison of methods for the determination of ß-aspartylglycine in faecal supernatants of leukemic patients treated with different antimicrobial agents. J Chromatogr 1982:232:55–62.PubMedGoogle Scholar
  12. 12.
    King A, Shannon K, Philips I. The in-vitro activity of ciprofloxacin compared with that of norfloxacin- and naladixic acid. J Antimicrob Chemother 1984;13:325–31.PubMedGoogle Scholar
  13. 13.
    Brumfitt W, Franklin I, Grady D, Hamilton-Miller JMT, Iliffe A. Changes in the pharmacokinetics of ciprofloxacin and faecal flora during administration of a 7-day course to human volunteers. Antimicrob Agents Chemother 1984;26:757–61.PubMedGoogle Scholar
  14. 14.
    Enzensberger R, Shah PM, Knothe H. Impact of oral ciprofloxacin on the faecal flora of healthy volunteers. Infection 1985:13:273–5.PubMedGoogle Scholar
  15. 15.
    Rozenberg-Arska M, Dekker AW, Verhoef J. Ciprofloxacin for selective decontamination of the digestive tract in patients with acute leukemia during remission induction treatment: the effect on faecal flora. J Infect Dis 1985;152:104–7.PubMedGoogle Scholar
  16. 16.
    Johanson WG, Pierce AK, Sanford JP. Changing pharyngeal bacterial flora of hospitalized patients: emergence of Gram-negative bacilli. N Engl J Med 1969;281:1137–40.PubMedGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1987

Authors and Affiliations

  • H. G. de Vries-Hospers
    • 1
  • G. W. Welling
    • 1
  • D. van der Waaij
    • 1
  1. 1.Laboratory for Medical MicrobiologyEZ GroningenThe Netherlands

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