Uptake of3H-GABA (γ-aminobutyric acid) and3H-leucine in the pancreatic islets and substantia nigra of the rat
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Isolated pancreatic islets and thin slices of substantia nigra (SN) of the rat were incubated in a medium containing3H-GABA or3H-leucine to test the activity of both tissues in the uptake of those substances. Pancreatic islets showed a low uptake of both3H-GABA and3H-leucine, but SN had a high activity in the uptake of3H-GABA, though not for3H-leucine. This suggests that GABA contained at high levels in the pancreatic islets plays some functional role other than in neurotransmission as in the central nervous system (CNS).
KeywordsNervous System Central Nervous System High Activity Functional Role Substantia Nigra
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- 4.Y. Okada, in: GABA in nervous system function, p. 235 Ed. E. Roberts, T.N. Chase and D.B. Tower. Raven Press, New York 1976.Google Scholar