, Volume 36, Issue 1, pp 107–107 | Cite as

Aryl hydrocarbon hydroxylase activity in type II alveolar lung cells

  • R. W. Teel
  • W. H. J. Douglas


Type II alveolar lung cells metabolize polycyclic aromatic hydrocarbons as indicated by measurements of aryl hydrocarbon hydroxylase activity and binding of tritium labeled benzo(a)pyrene to nuclear and cytoplasmic components.


Hydrocarbon Polycyclic Aromatic Hydrocarbon Pyrene Aromatic Hydrocarbon Tritium 


  1. 1.
    M. Pike, R. Gordon, B. Henderson, H. Bench and J. Soohosp, in: Persons at High Risk of Cancer, p. 225. Ed. J. F. Fraumeni, Jr. Academic Press, New York 1975.Google Scholar
  2. 2.
    A. Borgen, H. Darvey, N. Castagnoli, T. Crocker, R. Rasmussen and I. Wang, J. med. Chem.16, 502 (1973).CrossRefGoogle Scholar
  3. 3.
    S. Yang, D. McCourt, P. Roller and H. Gelboin, Proc. nat. Acad. Sci.73, 2594 (1976).CrossRefGoogle Scholar
  4. 4.
    W. Levin, A. Wood, H. Yagi, P. Dansette, D. Jerina and A. Conney, Proc. nat. Acad. Sci.73, 243 (1976).CrossRefGoogle Scholar
  5. 5.
    S. Hundley and R. Freudenthal, Cancer Res.37, 3120 (1977).PubMedGoogle Scholar
  6. 6.
    W. H. J. Douglas and M. Kaighn, In Vitro10, 230 (1974).CrossRefGoogle Scholar
  7. 7.
    D. Nebert and H. Gelboin, J. biol. Chem.243, 6242 (1968).PubMedGoogle Scholar
  8. 8.
    H. Gurtoo, J. Minowada, B. Paigen, N. Parker and N. Thompson, J. nat. Cancer Inst.59, 787 (1977).CrossRefGoogle Scholar
  9. 9.
    K. Ekelman and G. Milo, Cancer Res.38, 3026 (1978).PubMedGoogle Scholar
  10. 10.
    G. Toennies and F. Feng, Analyt. Biochem.11, 411 (1965).CrossRefGoogle Scholar
  11. 11.
    W. H. J. Douglas, P. Del Vecchio, R. Teel, R. Jones and P. Farrell, in: Lung Cells in Disease, p. 53. Ed. A. Bouhuys. North-Holland Biomedical Press, Amsterdam 1976.Google Scholar
  12. 12.
    M. Bittner and R. Ruddon, Molec. Pharm.12, 966 (1976).PubMedGoogle Scholar
  13. 13.
    C. Heidelberger, A. Rev. Biochem.44, 79 (1975).CrossRefGoogle Scholar
  14. 14.
    J. Pezzuto, M. Lea and C. Yang, Cancer Res.36, 3647 (1976).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • R. W. Teel
    • 1
    • 2
  • W. H. J. Douglas
    • 1
    • 2
  1. 1.Department of Physiology and Pharmacology, School of MedicineLoma Linda UniversityLoma Linda
  2. 2.Department of AnatomyTufts UniversityBostonUSA

Personalised recommendations