, Volume 36, Issue 1, pp 100–101 | Cite as

Effect of some nitrotoluenes on the biotransformation of xenobiotics in rats

  • R. D. Short
  • C. C. Lee


Male rats were treated with phenobarbital, a dinitrotoluene (2,4-DNT or 2,6-DNT), or 2,4,6-trinitrotoluene (2,4,6-TNT); and the biotransformation of model xenobiotics was determined. Phenobarbital produced a stimulation, and 2,6-DNT produced a biphasic effect in biotransformation.


Biotransformation Phenobarbital Biphasic Effect Nitrotoluenes Dinitrotoluene 


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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • R. D. Short
    • 1
  • C. C. Lee
    • 1
  1. 1.Pharmacology and ToxicologyMidwest Research InstituteKansas CityUSA

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