Effect of some nitrotoluenes on the biotransformation of xenobiotics in rats
Male rats were treated with phenobarbital, a dinitrotoluene (2,4-DNT or 2,6-DNT), or 2,4,6-trinitrotoluene (2,4,6-TNT); and the biotransformation of model xenobiotics was determined. Phenobarbital produced a stimulation, and 2,6-DNT produced a biphasic effect in biotransformation.
KeywordsBiotransformation Phenobarbital Biphasic Effect Nitrotoluenes Dinitrotoluene
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