, Volume 36, Issue 1, pp 94–95 | Cite as

Orotic acid prevents changes in cardiac sarcolemmal glycoproteins and contractility associated with muscular dystrophy in hamsters

  • L. E. Bailey


Orotic acid included in the diet of cardiomyopathic hamsters during the myolytic phase of the disease (30–60 days of age) prevented the reduction in cardiac sarcolemmal sialic acid, calcium binding, sialyltransferase activity and contractile activity associated with the cardiomyopathy.


Calcium Cardiomyopathy Sialic Acid Muscular Dystrophy Calcium Binding 


  1. 2.
    J.K. Perloff, A.C. de Leon, Jr, and D. O'Doherty, Circulation Res.41, 702 (1977).CrossRefGoogle Scholar
  2. 3.
    E. Bajusz, Am. Heart J.77, 686 (1969).CrossRefGoogle Scholar
  3. 4.
    T.S. Ma, J.C. Baker and L.E. Bailey, Cardiovasc. Res., in press (1979).Google Scholar
  4. 5.
    E. Bajusz, F. Homburger, J.R. Baker and P. Bogdonoff, Ann. N.Y. Acad. Sci.156, 396 (1969).CrossRefGoogle Scholar
  5. 6.
    M. Tada, J.O. Finney, Jr, H.H. Schwartz and A.M. Katz, J. molec. cell. Cardiol.4, 417 (1972).CrossRefGoogle Scholar
  6. 7.
    C.J. Limas and C. Limas, Biochim. biophys. Acta540, 543 (1978).CrossRefGoogle Scholar
  7. 8.
    J.S. Frank, E.A. Langer, L.M. Nudd and K. Seraydarian, Circulation Res.41, 702 (1977).CrossRefGoogle Scholar
  8. 9.
    G. Jasmin and B. Solymoss, Proc. Soc. exp. Biol. Med.149, 193 (1975).CrossRefGoogle Scholar
  9. 10.
    B. Mokri and A.G. Engel, Neurology25, 1111 (1975).CrossRefGoogle Scholar
  10. 11.
    N.A. Pickard, H.O. Gruemer, H.L. Verrill, E.R. Isaacs, M. Robinow, W.E. Nance, E.C. Myers and B. Goldsmith, New Engl. J. Med.299, 841 (1978).CrossRefGoogle Scholar
  11. 12.
    R.J. Bernacki, Eur. J. Biochem.58, 477 (1975).CrossRefGoogle Scholar
  12. 13.
    K.S. Hammond and D.S. Papermaster, Analyt. Biochem.74, 292 (1976).CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • L. E. Bailey
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineDalhousie UniversityHalifaxCanada

Personalised recommendations