Pharmaceutisch Weekblad

, Volume 6, Issue 5, pp 203–208 | Cite as

Pulsed proton NMR and solid-liquid fat ratio determinations in suppository vehicles and aminophylline suppositories

  • C. J. De Blaey
  • F. A. Varkevisser
  • A. Kalk
Original Articles


The physical state, melting behaviour and release rate of aminophylline suppositories were studied during storage. The fraction of non-crystallized fat, assessed by pulse NMR, varies between different vehicles. At room temperature several vehicles do not seem to be completely crystalline. Aging, as observed in prolonged melting time and a reduced release rate, is not expressed in a drastic reduction of the fraction of non-crystallized fat, as observed by NMR. On the contrary the mobility of the protons in the non-crystallized state is likely to offer a more promising tool to monitor aging.


Public Health Internal Medicine Physical State Release Rate Promising Tool 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • C. J. De Blaey
    • 1
  • F. A. Varkevisser
    • 2
  • A. Kalk
    • 3
  1. 1.Royal Dutch Association for Advancement of PharmacyJL The HagueThe Netherlands
  2. 2.Faculty of PharmacyUniversity of LeidenRA LeidenThe Netherlands
  3. 3.Faculty of PharmacyUniversity of UtrechtGH UtrechtThe Netherlands

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