Pharmaceutisch Weekblad

, Volume 6, Issue 5, pp 185–194 | Cite as

Development and optimization of pharmaceutical formulations using a simplex lattice design

  • R. Huisman
  • H. V. Van Kamp
  • J. W. Weyland
  • D. A. Doornbos
  • G. K. Bolhuis
  • C. F. Lerk
Original Articles


The composition of pharmaceutical formulations is often subject to trial and error. This approach is time consuming and unreliable in finding the best formulation. Optimization by means of an experimental design might be helpful in shortening experimenting time. Such a design with the concomitant mathematical models, reveals effects and interactions of the variables. The independent variables are the different compositions of the mixtures of the chosen ingredients [drug(s) and excipients]. The dependent variables are the properties (responses) of the formulation. When all responses of interest have been expressed in models that describe the response as a function of the composition of the mixture, the models can be combined graphically or mathematically to find a composition satisfying all demands. In this paper an introduction to the use of mixture designs will be given by means of a theoretical part and an example: optimizing a tablet formulation consisting of excipients only.


Public Health Internal Medicine Mathematical Model Pharmaceutical Formulation Tablet Formulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • R. Huisman
    • 1
  • H. V. Van Kamp
    • 1
  • J. W. Weyland
    • 2
  • D. A. Doornbos
    • 2
  • G. K. Bolhuis
    • 1
  • C. F. Lerk
    • 1
  1. 1.Laboratory for Pharmaceutical Technology and DispensingUniversity of GroningenAW GroningenThe Netherlands
  2. 2.Research Group Optimization, Laboratory for Analytical and Pharmaceutical ChemistryUniversity of GroningenAW GroningenThe Netherlands

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