Pharmaceutisch Weekblad

, Volume 13, Issue 5, pp 215–219 | Cite as


A pharmaco-epidemiological study of its use in a university hospital
  • D. M. Burger
  • Y. A. Hekster
  • W. P. M. Hopman
  • R. Does


A pharmaco-epidemiologic study in hospitalized patients was carried out in order to establish the place and use of omeprazole (Losec®), a new and promising drug in the treatment of acid-related diseases. A comparison is made with cimetidine and ranitidine use. It appeared that prescribed omeprazole doses were high in relation to the established defined daily doses and that substitution of H2 receptor antagonists by omeprazole led to tremendously increased drug costs. From the clinical indication data it could be established that the drug was prescribed appropriately.


Cimetidine Costs and cost analysis Drug utilization Epidemiology Omeprazole Ranitidine 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • D. M. Burger
    • 1
  • Y. A. Hekster
    • 1
  • W. P. M. Hopman
    • 2
  • R. Does
    • 3
  1. 1.Department of Clinical PharmacyUniversity Hospital NijmegenHB Nijmegenthe Netherlands
  2. 2.Department of Gastro-enterologyUniversity Hospital Nijmegenthe Netherlands
  3. 3.Department of General SurgeryUniversity Hospital Nijmegenthe Netherlands

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