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Pharmaceutisch Weekblad

, Volume 13, Issue 3, pp 142–147 | Cite as

Pharmacokinetics of nicomorphine and its metabolites in man after epidural administration

  • P. M. Koopman-Kimenai
  • T. B. Vree
  • M. A. W. M. Hasenbos
  • E. W. G. Weber
  • C. P. W. G. M. Verweij-Van Wissen
  • L. H. D. J. Booij
Articles

Abstract

In ten patients who received an epidural injection of 15 mg of nicomorphine, the compound was relatively slowly released from the epidural space and was found in plasma for approximately 1.5 h. Nicomorphine is relatively slowly metabolized into 6-nicotinoylmorphine and morphine. The rate of release is patient-dependent. The relative AUC values are 15.3% for nicomorphine, 23.9% for 6-nicotinoylmorphine and 60.8% for morphine. The mean clinical effect lasts for 18.2±10.1 h.

Keywords

Analgesics Injections, intrathecal Metabolism Narcotics Nicomorphine Pharmacokinetics 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • P. M. Koopman-Kimenai
    • 1
  • T. B. Vree
    • 1
  • M. A. W. M. Hasenbos
    • 2
  • E. W. G. Weber
    • 2
  • C. P. W. G. M. Verweij-Van Wissen
    • 1
  • L. H. D. J. Booij
    • 2
  1. 1.Department of Clinical PharmacyAcademic Hospital Nijmegen Sint RadboudHB Nijmegenthe Netherlands
  2. 2.Department of AnaesthesiologyAcademic Hospital Nijmegen Sint Radboudthe Netherlands

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