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Pharmaceutisch Weekblad

, Volume 12, Issue 5, pp 184–187 | Cite as

Comparative bioavailability study of two brands of prazosin-containing tablets in healthy volunteers

  • P. J. M. Guelen
  • T. J. Janssen
  • M. H. Lam
  • T. B. Vree
  • P. S. Exler
Articles
  • 85 Downloads

Abstract

The bioavailability of two prazosin formulations was studied in 12 healthy volunteers. 1 Subject left the study. Based on the statistical tests of the pharmacokinetic parameters of prazosin in 11 volunteers, such ast1/2,Cmax,tmax and AUC, it could be concluded that both preparations had comparable bioavailabilities.

Keywords

Biological availability Clinical trials Pharmacokinetics Prazosin 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • P. J. M. Guelen
    • 1
  • T. J. Janssen
    • 1
  • M. H. Lam
    • 1
  • T. B. Vree
    • 2
  • P. S. Exler
    • 3
  1. 1.Farma Research BVAA Ravensteinthe Netherlands
  2. 2.Department of Clinical PharmacyUniversity Hospital NijmegenHB Nijmegenthe Netherlands
  3. 3.Farmaver BVDJ Zevenaarthe Netherlands

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