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Pharmaceutisch Weekblad

, Volume 8, Issue 1, pp 35–39 | Cite as

Pharmacokinetics of intravenously administered ciprofloxacin in intensive care patients with acute renal failure

  • M. S. C. Dirksen
  • T. B. Vree
Quinolones in Perspective

Abstract

The pharmacokinetics of ciprofloxacin after a single intravenous administration of 100 mg were studied in intensive care patients with an acute renal impairment. There was no correlation found between the creatinine clearance and the renal clearance of ciprofloxacin. This applies to the entire group of patients. The decrease in renal clearance of ciprofloxacin was, however, more pronounced than the change in the elimination half-life, suggesting an important extra-renal elimination of the drug.

Key words

Ciprofloxacin Drug evaluation Intensive care Kidney failure, acute Pharmacokinetics Renal clearance 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1986

Authors and Affiliations

  • M. S. C. Dirksen
    • 1
  • T. B. Vree
    • 2
  1. 1.Department of Intensive Care, Sint Radboud HospitalCatholic University of NijmegenHB NijmegenThe Netherlands
  2. 2.Department of Anesthesiology, Sint Radboud HospitalCatholic University of NijmegenHB NijmegenThe Netherlands

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