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Pharmaceutisch Weekblad

, Volume 8, Issue 1, pp 29–34 | Cite as

Pharmacokinetics: metabolism and renal excretion of quinolones in man

  • T. B. Vree
  • W. J. A. Wijnands
  • P. J. M. Guelen
  • A. M. Baars
  • Y. A. Hekster
Quinolones in Perspective

Abstract

The quinolones are relatively poorly absorbed from the gastrointestinal tract. The elimination proceeds mainly by renal excretion. The half-life of elimination depends on the molecular structure and varies between 2 and 10 h. Impaired kidney function is expected to increase the half-life of elimination. though this effect is not always observed. Since the 4-oxo-metabolites show a higher renal clearance than the parent drug, renal impairment will result in a cumulation of the metabolites in the body.

Key words

Absorption Kidney failure Metabolism Pharmacokinetics Quinolones Renal excretion 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1986

Authors and Affiliations

  • T. B. Vree
    • 1
    • 4
  • W. J. A. Wijnands
    • 2
  • P. J. M. Guelen
    • 3
  • A. M. Baars
    • 1
  • Y. A. Hekster
    • 1
  1. 1.Department of Clinical PharmacySt. Radboud HospitalHB NijmegenThe Netherlands
  2. 2.Department of Pulmonary DiseasesSt. Radboud HospitalHB NijmegenThe Netherlands
  3. 3.Farma ResearchNV NijmegenThe Netherlands
  4. 4.Department of AnaesthesiologySt. Radboud HospitalHB NijmegenThe Netherlands

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