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Pharmaceutisch Weekblad

, Volume 7, Issue 3, pp 109–116 | Cite as

Aspects of the chemical stability of doxorubicin and seven other anthracydines in acidic solution

  • J. H. Beijnen
  • G. Wiese
  • W. J. M. Underberg
Original Articles

Abstract

The degradation of doxorubicin in acidic medium has been investigated using a stability indicating high pressure liquid chromatographic assay. Influences of temperature, pH and ionic strength on the degradation rate are quantified. The stability of doxorubicin at 50°C is compared with those of seven related anthracyclines. The aglycone degradation products are characterized by mass spectrometry and by chromatography.

Keywords

Public Health Mass Spectrometry Internal Medicine High Pressure Doxorubicin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1985

Authors and Affiliations

  • J. H. Beijnen
    • 1
  • G. Wiese
    • 1
  • W. J. M. Underberg
    • 1
  1. 1.Department of Analytical Pharmacy, Subfaculty of PharmacyState University of UtrechtGH UtrechtThe Netherlands

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