Pharmaceutisch Weekblad

, Volume 7, Issue 3, pp 109–116 | Cite as

Aspects of the chemical stability of doxorubicin and seven other anthracydines in acidic solution

  • J. H. Beijnen
  • G. Wiese
  • W. J. M. Underberg
Original Articles


The degradation of doxorubicin in acidic medium has been investigated using a stability indicating high pressure liquid chromatographic assay. Influences of temperature, pH and ionic strength on the degradation rate are quantified. The stability of doxorubicin at 50°C is compared with those of seven related anthracyclines. The aglycone degradation products are characterized by mass spectrometry and by chromatography.


Public Health Mass Spectrometry Internal Medicine High Pressure Doxorubicin 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1985

Authors and Affiliations

  • J. H. Beijnen
    • 1
  • G. Wiese
    • 1
  • W. J. M. Underberg
    • 1
  1. 1.Department of Analytical Pharmacy, Subfaculty of PharmacyState University of UtrechtGH UtrechtThe Netherlands

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