Pharmaceutisch Weekblad

, Volume 7, Issue 3, pp 104–108 | Cite as

Determination of the stability of tetracycline suspensions by high performance liquid chromatography

  • A. Grobben-Verpoorten
  • Kabala Dihuidi
  • E. Roets
  • J. Hoogmartens
  • H. Vanderhaeghe
Original Articles


High performance liquid chromatography was used to examine the stability of tetracycline suspensions, prepared according to the Formulary of the Dutch Pharmacists and the National Formulary v (Belgium). The influence of the nature of the buffer salt, of the pH, and of the temperature and time of storage are discussed. At slightly acid pH (4 to 5.5) and at room temperature suspensions are stable for at least three months.


Public Health Internal Medicine Liquid Chromatography High Performance Liquid Chromatography Tetracycline 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1985

Authors and Affiliations

  • A. Grobben-Verpoorten
    • 1
  • Kabala Dihuidi
    • 1
  • E. Roets
    • 1
  • J. Hoogmartens
    • 1
  • H. Vanderhaeghe
    • 1
  1. 1.Institute for Pharmaceutical Sciences, Laboratory for Pharmaceutical ChemistryCatholic University of LeuvenLeuvenBelgium

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