Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 292–295 | Cite as

Antibiotic prophylaxis in vaginal hysterectomy

Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin
  • W. K. Brouwer
  • K. M. Kuiper
  • J. A. A. Hoogkamp-Korstanje
Antibiotics in Gynaecology and Obstetrics


The prophylactic efficacy of three intravenous doses of cefuroxime 1,500 mg plus metronidazole 500 mg in vaginal hysterectomy was compared with placebo in a prospective double-blind randomized study. Febrile morbidity occurred in 13 of 26 patients in the placebo group and 0 of 27 patients in the study group. In a second prospective randomized study, the efficacy of intravenous ciprofloxacin (200 mg single dose) was compared with the cefuroxime plus metronidazole regimen. Febrile morbidity was found in 3 of 54 patients in the ciprofloxacin group, but in none of the 58 patients in the cefuroxime plus metronidazole group.


Cefuroxime Ciprofloxacin Drug therapy Hysterectomy Metronidazole Pre-operative care 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Osborne NG, Wright RC. Effect of preoperative scrub on the bacterial flora of the endocervix and vagina. Obstet Gynecol 1977;50:148–51.PubMedGoogle Scholar
  2. 2.
    Brouwer WK, Hoogkamp-Korstanje JAA, Kuiper KM. Single shot ciprofloxacin, cefuroxim plus metronidazole and placebo as prophylaxis in vaginal hysterectomy. Int J Exp Clin Chemother 1990;3:172–7.Google Scholar
  3. 3.
    Duff P, Park R. Antibiotic prophylaxis in vaginal hysterectomy: a review. Obstet Gynecol 1980;50:193–202.Google Scholar
  4. 4.
    Grossman JH, Greco TP, Minkin MJ, Adams RL, Hierholzer WJ, Andriole OT. Prophylactic antibiotics in gynaecologic surgery. Obstet Gynecol 1979;53:537–44.PubMedGoogle Scholar
  5. 5.
    Hemsell DL, Cunningham G, Kappus S, Nobles B. Cefoxitin for prophylaxis in premenopausal women undergoing vaginal hysterectomy. Obstet Gynecol 1980;56:629–34.PubMedGoogle Scholar
  6. 6.
    Mendelson J, Portnay J, De Saint Victor JR, Gelfand MM. Effect of single and multidose cephradine prophylaxis on infectious morbidity of vaginal hysterectomy. Obstet Gynecol 1979;53:31–5.PubMedGoogle Scholar
  7. 7.
    Mickel A, Curole D, Lewis C. Cefoxitin sodium: double-blind vaginal hysterectomy prophylaxis in premenopausal patients. Obstet Gynecol 1980;56:222–5.PubMedGoogle Scholar
  8. 8.
    Roberts JM, Homesley HD. Low-dose carbenicillin prophylaxis for vaginal and abdominal hysterectomy. Obstet Gynecol 1978;52:83–7.PubMedGoogle Scholar
  9. 9.
    Mathews DD, Agarwal V, Gordon AM, et al. A double-blind trial of single dose chemoprophylaxe with cotrimoxazole during vaginal hysterectomy and repair. Br J Obstet Gynaecol 1979;86:737–40.PubMedGoogle Scholar
  10. 10.
    Hamod KA, Spence MR, Rosenshein NB, et al. Single-dose and multidose prophylaxis in vaginal hysterectomy. A comparison of sodium cepholatin and metronidazole. Am J Obstet Gynecol 1980;136:976–9.PubMedGoogle Scholar


  1. 1a.
    McDonald PJ, Sanders R, Turnidge J, et al. Optimal duration of cefotaxime prophylaxis in abdominal and vaginal hysterectomy. Drugs 1988;35(Suppl 2):216–20.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • W. K. Brouwer
    • 1
  • K. M. Kuiper
    • 1
  • J. A. A. Hoogkamp-Korstanje
    • 2
  1. 1.Medical Centre LeeuwardenAD Leeuwardenthe Netherlands
  2. 2.Laboratory for Public HealthEN Leeuwardenthe Netherlands

Personalised recommendations