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Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 289–291 | Cite as

Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis

  • F. W. Eckenhausen
  • P. L. Jonker
Antibiotics in Gynaecology and Obstetrics

Abstract

Two consecutive open studies were performed of the efficacy of a prophylactic cefuroxime/metronidazole combination in abdominal hysterectomy. The first group received a 24-h regimen, the second group a single pre-operative dose. The incidence of post-operative wound infections and urinary tract infections were similar in both groups [wound infections in 1/75 versus 2/84 patients (NS), urinary tract infections 4/75 versus 3/84 patients (NS), respectively, in the 24-h group and single-dose group]. No significant differences in other parameters, such as pyrexia and duration of post-operative hospitalization, could be detected.

Keywords

Antibiotics Cefuroxime Clinical trials Hysterectomy Metronidazole Preoperative care 

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References

  1. 1.
    Shapiro N, Munoz A, Tager IB, et al. Risk factors for infection at the operative site after abdominal or vaginal hysterectomy. N Engl J Med 1982;307:1661–6.PubMedGoogle Scholar
  2. 2.
    Cartwright PS, Pittaway DE, Jones III HW, et al. The use of prophylactic antibiotics in obstetrics and gynaecology. A review. Obstet Gynecol Surv 1984;39:537–53.PubMedGoogle Scholar
  3. 3.
    Shapiro N, Schoenbaum SC, Tager IB, et al. Benefitcost analysis of antimicrobial prophylaxis in abdominal and vaginal hysterectomy. JAMA 1983;249:1290–4.CrossRefPubMedGoogle Scholar
  4. 4.
    Hirsch HA. Prophylactic antibiotics in obstetrics and gynecology. Am J Med 1985;78(Suppl B):170–6.CrossRefPubMedGoogle Scholar
  5. 5.
    Wttewaall-Evelaar EW, Kroeks MV, Verbrugh HA. The value of prophylaxis in abdominal hysterectomy, a meta-analysis. Abstracts of the twenty-ninth interscience conference on antimicrobial agents and chemotherapy Washington: American Society for Microbiology, 1989:abstract 399.Google Scholar
  6. 6.
    Wttewaall-Evelaar EW. Meta-analysis of randomized controlled trials of antibiotic prophylaxis in abdominal hysterectomy. Pharm Weekbl [Sci] 1990;12:296–9.Google Scholar
  7. 7.
    Brouwer WK, Kuiper KM, Langbroek W. The efficacy of prophylaxis with cefuroxime and metronidazol in gynecological surgery. Res Clin Forums 1984;6:25–31.Google Scholar
  8. 8.
    Gonen R, Hakim M, Somberg I, et al. Short-term prophylaxis for elective abdominal hysterectomy: how short? Eur J Obstet Gynecol Reprod Biol 1985;20:229–34.CrossRefPubMedGoogle Scholar
  9. 9.
    Jandial L, Reid TM, Jandial V, et al. Prophylactic use of cefuroxime in major gynecological surgery. Proc R Soc Med 1981;38:41–9.Google Scholar
  10. 10.
    Boodt PJ, Snijders WP, Janknegt R. Single-dose prophylaxis in hysterectomies. An interim analysis. Pharm Weekbl [Sci] 1990;12:280–3.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • F. W. Eckenhausen
    • 1
  • P. L. Jonker
    • 2
  1. 1.Department of Obstetrics and GynaecologyRefaja HospitalHE Stadskanaalthe Netherlands
  2. 2.Medical DepartmentGlaxo BVML Nieuwegeinthe Netherlands

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