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Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 243–246 | Cite as

High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man

  • T. B. Vree
  • E. W. J. Beneken Kolmer
  • Y. A. Hekster
Articles

Abstract

A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, < 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.

Keywords

Chromatography, high pressure liquid Clearance Metabolism Pharmacokinetics Sulfaphenazole 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • T. B. Vree
    • 1
  • E. W. J. Beneken Kolmer
    • 1
  • Y. A. Hekster
    • 1
  1. 1.Department of Clinical PharmacyUniversity Hospital Nijmegen Saint RadboudHB Nijmegenthe Netherlands

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