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Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 240–242 | Cite as

Stability of somatostatin in total parenteral nutrition

  • J. B. Montoro
  • R. Galard
  • R. Catalan
  • J. Martinez
  • P. Salvador
  • P. Sabin
Articles

Abstract

The stability of somatostatin, added to a total parenteral nutrition formula, in glass containers and in plastic ethylene vinyl acetate containers was investigated. The somatostatin concentration decreased immediately from 3μg/ml to 0.3–0.6μg/ml after addition to the emulsion. In spite of this rapid decrease, somatostatin concentrations remained stable with values of 0.4–0.7μg/ml during the follow-up period (24 h). These findings could be explained assuming adsorption to the surface of the container.

Keywords

Adsorption Drug stability Parenteral nutrition Somatostatin 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • J. B. Montoro
    • 1
  • R. Galard
    • 2
  • R. Catalan
    • 2
  • J. Martinez
    • 1
  • P. Salvador
    • 1
  • P. Sabin
    • 1
  1. 1.Hospital Pharmacy ServiceHospital General Vall d'HebronBarcelonaSpain
  2. 2.Biochemistry ServiceHospital General Vall d'HebronBarcelona

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