Pharmaceutisch Weekblad

, Volume 12, Issue 3, pp 104–106 | Cite as

Activity of cefotiam in combination with beta-lactam antibiotics on enterobacterial hospital strains

  • R. Vanhoof
  • J. M. Hubrechts
  • H. J. Nyssen
  • E. Nulens
  • J. Leger
  • N. de Schepper
  • E. Kupperberg
  • M. L. Couvreur
Research Reports


By using checkerboard titrations the effect of cefotiam combined with different beta-lactam antibiotics on fifty strains of Enterobacteriaceae moderately susceptible (minimal inhibiting concentration ⩾8 mg/l) or resistant (minimal inhibiting concentration ⩾64 mg/l) to cefotiam was evaluated. The following compounds were tested: cefamandole, cefazolin, cefmenoxime, cefotaxime, cefotiam, ceftazidime, cefuroxime, mecillinam and piperacillin. The synergistic effect varied markedly. The combination cefotiam—mecillinam showed the highest rate of synergistic activity. Antagonism was found in 1% of the combinations.


Antibiotics, lactam Cefotiam Drug therapy, combination Enterobacteriaceae 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • R. Vanhoof
    • 1
  • J. M. Hubrechts
    • 2
  • H. J. Nyssen
    • 1
  • E. Nulens
    • 1
  • J. Leger
    • 1
  • N. de Schepper
    • 1
  • E. Kupperberg
    • 3
  • M. L. Couvreur
    • 1
  1. 1.Unit of Antibiotic ResearchInstitute Pasteur of BrabantBrusselsBelgium
  2. 2.Department of Clinical MicrobiologyJ. Bracops HospitalBrusselsBelgium
  3. 3.Roussel SABrusselsBelgium

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