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Pharmaceutisch Weekblad

, Volume 12, Issue 3, pp 81–90 | Cite as

Aminoglycoside therapy

Current use and future prospects
  • R. Janknegt
Review Articles

Abstract

The microbiological, pharmacokinetic, toxicological and clinical aspects of aminoglycosides are reviewed. Aminoglycosides still have an important place in serious infections in neutropenic patients, endocarditis andPseudomonas aeruginosa infections, all in combination with beta-lactams. Monotherapy (with streptomycin) is indicated in less common diseases like tularaemia and bubonic plague. Several experimental studies support a oncedaily dosing regimen for aminoglycosides (comparable or better efficacy with less ototoxicity and nephrotoxicity). Only a very limited number of prospective comparative studies have been performed, and much more data on efficacy, development of resistance and toxicity is needed before once-daily administration can be recommended. The choice of an aminoglycoside should be based primarily on the local sensitivity patterns and cost. Differences in ototoxicity and nephrotoxicity are usually minor. If the acquisition costs of amikacin decline, it is to be expected that amikacin will be the aminoglycoside of choice.

Keywords

Amikacin Aminoglycosides Drug administration schedule Gentamicins Netilmicin Pharmacokinetics Tobramycin Toxicology 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • R. Janknegt
    • 1
  1. 1.Department of Clinical PharmacyMaasland HospitalMB SittardThe Netherlands

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