Pharmaceutisch Weekblad

, Volume 13, Issue 1, pp 18–23 | Cite as

Preparation of lyophilized heat-treated cryoprecipitates from a small pool of plasma obtained by apheresis

  • D. P. Allersma
  • E. Roeffen
  • J. A. Van der Does
  • E. Briët


A method was developed for the batch-wise production of small-pool lyophilized heat-treated cryoprecipitates in a regional Blood Bank. Ten vials of final product were derived from twenty 600 g apheresis plasma donations. We found 384 IU of factor VIII per vial and a specific activity of 0.20 IU per mg total protein. Production recovery was 340 IU of factor VIII per kg plasma. The method was easy to perform and gave a product of good quality.


Blood banks Drug compounding Factor VIII Freeze drying Plasma 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • D. P. Allersma
    • 1
  • E. Roeffen
    • 2
  • J. A. Van der Does
    • 2
  • E. Briët
    • 3
  1. 1.Central Pharmacy of the Hospitals of The HagueAC The HagueThe Netherlands
  2. 2.Red Cross Blood BankCJ The HagueThe Netherlands
  3. 3.Department of HaematologyUniversity Hospital LeidenRA LeidenThe Netherlands

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