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Pharmaceutisch Weekblad

, Volume 13, Issue 1, pp 13–17 | Cite as

Butyl-p-aminobenzoate

Preparation, characterization and quality control of a suspension injection for epidural analgesia
  • R. J. E. Grouls
  • E. W. Ackerman
  • E. J. A. Machielsen
  • H. H. M. Korsten
Articles

Abstract

The conditions for the preparation of a 10% butyl-p-aminobenzoate suspension for epidural administration were investigated. Pharmaceutically acceptable suspensions are composed of butyl-p-aminobenzoate particles dispersed in a solvent consisting of the surfactant polysorbate 80 added to normal saline in a concentration of 0.25 mg/ml. pH Correction is not necessary. The suspensions are sterilized at 120°C followed by special milling procedures to accomplish acceptable particle size. Butyl-p-aminobenzoate suspensions are stable at 4°C during a period of at least four weeks.

Keywords

Administration, epidural Butyl-p-aminobenzoate Drug compounding Particle size Polyethylene glycol 3350 Polysorbate 80 Quality control Suspensions 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • R. J. E. Grouls
    • 1
  • E. W. Ackerman
    • 1
  • E. J. A. Machielsen
    • 1
  • H. H. M. Korsten
    • 2
  1. 1.Hospital PharmacyCatharina HospitalZA EindhovenThe Netherlands
  2. 2.Department of AnaesthesiologyCatharina HospitalEindhoven

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