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Pharmaceutisch Weekblad

, Volume 4, Issue 2, pp 38–42 | Cite as

Microcomputer-controlled determination of dissociation constants of sulfanilamides and stability constants of the related silver complexes

  • G. J. Boelema
  • A. Bult
  • H. J. Metting
  • B. L. Bajema
  • D. A. Doornbos
Original Articles

Abstract

As a contribution to the structure—activity relationship of silver sulfanilamide complexes, the pKa-values of thirteen sulfanilamides and the log K-values of their related silver compounds were determined using a microcomputer-controlled titrator which determines the silver ion concentration and hydrogen ion concentration in a combined measurement.

Predictions on antibacterial effectiveness and the risk of sensitization reactions of some of the investigated silver sulfanilamides are made on the basis of the conditional stability constants computed from the pKa- and log K-values at pH = 7.4.

Keywords

Public Health Hydrogen Internal Medicine Stability Constant Dissociation Constant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bell, P.H., andR.O. Roblin Jr. (1942)J. Am. Chem. Soc. 64, 2905.CrossRefGoogle Scholar
  2. Boelema, G.J. (1982) Ph.D. thesis, Groningen.Google Scholar
  3. Bult, A. (1981)Pharm. Weekbl. Sci. Ed. 3, I-II.Google Scholar
  4. Bult, A., andH.B. Klasen (1978)J. Pharm. Sci. 67, 284–287.PubMedGoogle Scholar
  5. Bult, A., B.L. Bajema, H.B. Klasen, H.J. Metting andCh.L. Fox (1981)Pharm. Weekbl. Sci. Ed. 3, 79–81.Google Scholar
  6. Fox, Ch.L., andS.M. Modak (1974)Antimicrobial Agents Chernotherap. 5, 582–588.Google Scholar
  7. Meites, L. (1974)General multiparametric curve fitting program CFT3. Clarkson College of Technology, Potsdam, NY.Google Scholar
  8. Nesbitt, R.U., andB.J. Sandmann (1978)J. Pharm. Sci. 67, 1012–1017.PubMedGoogle Scholar
  9. Sakurai, H., andT. Ishimitsu (1980)Talanta 27, 293–298.CrossRefGoogle Scholar
  10. Still, E., andR. Sara (1977)J. Chem. Educ. 54, 348.Google Scholar
  11. Wysor, M.S. (1975)Chemotherapy 21, 302–310.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • G. J. Boelema
    • 1
  • A. Bult
    • 2
  • H. J. Metting
    • 1
  • B. L. Bajema
    • 1
  • D. A. Doornbos
    • 1
  1. 1.Laboratory of Pharmaceutical and Analytical ChemistryResearch Group OptimizationAW GroningenThe Netherlands
  2. 2.Gorlaeus LaboratoriesState UniversityRA LeidenThe Netherlands

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