Pharmaceutisch Weekblad

, Volume 4, Issue 2, pp 25–31 | Cite as

Hexamethylmelamine and hexamethylmelamine hydrochloride

  • H. P. C. Van De Vaart-Van Zutphen
  • C. F. A. Smulders
  • J. Renema
  • A. Hulshoff
Review Articles


Methods of analysis of the anticancer drug hexamethylmelamine, its physicochemical properties, its therapeutic uses and its fatein vivo upon oral administration, are described. The data are taken in part from the literature, in part from our own studies.

The low solubility of hexamethylmelamine in water has prevented the parenteral administration of the drug to humans. The preparation of the water-soluble monohydrochloride of hexamethylmelamine, which may be suitable for this purpose, is reported, as well as its physicochemical characteristics and methods of analysis.


Public Health Internal Medicine Hydrochloride Oral Administration Physicochemical Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • H. P. C. Van De Vaart-Van Zutphen
    • 1
  • C. F. A. Smulders
    • 1
  • J. Renema
    • 1
  • A. Hulshoff
    • 1
  1. 1.Pharmaceutical Laboratory, Department of Analytical PharmacyUniversity of UtrechtGH UtrechtThe Netherlands

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